健脾益肾汤联合依帕司他治疗早期糖尿病肾病临床研究
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R587.2

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Clinical Study on Jianpi Yishen Tang Combined with Epalrestat for Early Diabetic Kidney Disease
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    摘要:

    目的:观察健脾益肾汤联合依帕司他治疗早期糖尿病肾病(DKD) 的临床疗效。方法:选取早期DKD 患者84 例,按随机数字表法分为观察组和对照组各42 例。2 组均予优质低蛋白饮食,控制血糖血压和维持电解质酸碱平衡等基础治疗。对照组予以依帕司他片口服,观察组在对照组基础上加用健脾益肾汤,2 组均连用12 周。评价2 组临床疗效,比较2 组治疗前后中医证候评分、肾功能指标[血清肌酐(SCr)、尿微量白蛋白排泄率(UAER) 和肾小球滤过率(GFR)] 的变化。结果:观察组总有效率为95.24%,高于对照组80.95%,差异有统计学意义(P<0.05)。治疗前,2 组腰膝酸软、神疲乏力、肢体浮肿评分比较,差异无统计学意义(P>0.05)。治疗后,2 组各项症状评分较治疗前下降(P<0.05),且观察组各项症状评分均低于对照组(P<0.05)。治疗前,2 组SCr、UAER 及GFR 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组SCr、UAER 水平较治疗前下降,GFR 较治疗前上升(P<0.05);且观察组SCr、UAER 水平低于对照组,GFR水平高于对照组(P<0.05)。结论:健脾益肾汤联合依帕司他治疗早期DKD 患者的疗效确切,能明显改善临床症状,保护肾功能。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Jianpi Yishen tang combined with epalrestat for early diabetic kidney disease(DKD). Methods: A total of 84 cases of DKD patients at early stage were selected and divided into the observation group and the control group according to the random number table method,with 42 cases in each group. Both groups were given basic treatment including high-quality low protein diet, control of blood glucose and blood pressure, and the maintenance of electrolyte and acidbase balance. The control group was given oral administration of epalrestat tablets, and the observation group was additionally treated with Jianpi Yishen tang based on the treatment of the control group. Both groups were treated for 12 weeks. After treatment,the clinical effects in the two groups were evaluated. Before and after treatment,the changes in Chinese medicine syndrome scores and kidney function indexes including serum creatinine(SCr),urinary albumin excretion rate(UAER) and glomerular filtration rate(GFR) in the two groups were compared. Results: The total effective rate was 95.24% in the observation group, higher than that of 80.95% in the control group, the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of soreness and weakness of waist and knees,mental fatigue and lack of strength,and limb swelling between the two groups(P>0.05). After treatment, the scores of each symptom in the two groups were decreased when compared with those before treatment(P<0.05),and the symptom scores in the observation group were lower than those in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of SCr,UAER and GFR between the two groups(P>0.05). After treatment,the levels of SCr and UAER in the two groups were decreased when compared with those before treatment, and GFR levels were increased(P<0.05);the levels of SCr and UAER in the observation group were lower than those in the control group, and GFR level was higher(P<0.05). Conclusion: Jianpi Yishen tang combined with epalrestat for patients with early DKD has a definite curative effect,which can effectively improve clinical symptoms and protect kidney function.

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任传永,宣少平,张青森,沈诤.健脾益肾汤联合依帕司他治疗早期糖尿病肾病临床研究[J].新中医,2022,54(17):111-114

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  • 在线发布日期: 2022-09-06
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