Abstract：Objective：To observe the effect of Hushen Mitang tang on blood glucose control，kidney function and levels of visfatin and resistin in serum of patients with gestational diabetes mellitus. Methods： A total of 104 cases of patients with gestational diabetes mellitus were randomly divided into Group A and Group B according to the envelope method， with 52 cases in each group. Group A was given routine treatment，and Group B was additionally treated with Hushen Mitang tang based on the treatment of Group A. The levels of blood glucose，blood urea nitrogen(BUN)，serum creatinine(SCr)，serum β2-microglobulin (β2- MG)， uric acid(UA)， and visfatin and resistin in serum， the incidence of maternal- infant adverse events and the incidence of adverse reactions in the two groups were compared. Results： After 7 and 14 days of treatment，fasting blood glucose and two- hour postprandial blood glucose in the two groups were decreased when compared with those before treatment(P＜0.05)； after seven days of treatment， fasting blood glucose and two-hour postprandial blood glucose in Group B were lower than those in Group A (P＜0.05)；after 14 days of treatment，fasting blood glucose and two- hour postprandial blood glucose in Group B were lower than those in Group A(P＜0.05). After treatment，the levels of BUN，SCr，β2- Mg， UA，and visfatin and resistin in serum in the two groups were decreased when compared with those before treatment(P＜0.05)；the levels of BUN，SCr，β2-Mg，UA，and visfatin and resistin in serum in Group B were lower than those in Group A(P＜0.05). After treatment， the incidence of adverse events including pregnancy-induced hypertension in pregnant women，polyhydramnios，ketoacidosis，premature delivery， cesarean section and neonatal macrosomia， respiratory distress syndrome and hypoglycemia in Group B was lower than that in Group A(P＜0.05)；there was no significant difference being found in the comparison of abortion rates and the incidence of fetal growth restriction and deformity between the two groups(P＞ 0.05). During treatment， there was no adverse reaction in the two groups. Conclusion： Hushen Mitang tang for gestational diabetes mellitus has a good effect on glucose control，and can significantly reduce the levels of visfatin and resistin in serum， protect kidney function and improve maternal- infant outcomes， with high safety.