连花清瘟胶囊辅助治疗慢性阻塞性肺疾病疗效及对肺功能、炎性因子的影响
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R563.9

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Curative Effect of Lianhua Qingwen Capsules on Assisting Chronic Obstructive Pulmonary Disease and Its Influence on Lung Function and Inflammatory Factors
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    摘要:

    目的:观察连花清瘟胶囊辅助治疗慢性阻塞性肺疾病(COPD) 的疗效及对肺功能、炎性因子的影响。方法:将100 例COPD 患者以简单随机化法分为对照组与观察组各50 例。对照组采取常规对症治疗,治疗组在对照组基础上以连花清瘟胶囊辅助治疗。连续治疗7 d 后,评估2 组临床疗效,比较2 组治疗前后中医证候积分、肺功能及炎性因子水平。结果:治疗组临床总有效率88.00%,高于对照组72.00%(P<0.05)。与同组治疗前比较,治疗后2 组中医证候积分及血清白细胞介素-8(IL-8)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α) 水平均降低(P<0.05),第1 秒用力呼气容积占预计值的百分比(FEV1%)、FEV1 占用力肺活量的百分比(FEV1/FVC) 水平均升高(P<0.05)。与对照组治疗后比较,治疗组治疗后中医证候积分及IL-8、IL-17、TNF-α 水平均较低(P<0.05),FEV1%、FEV1/FVC 水平均较高(P<0.05)。结论:连花清瘟胶囊辅助治疗COPD 疗效确切,有利于缓解患者临床症状,改善肺功能,并抑制炎症因子释放。

    Abstract:

    Abstract:Objective:To observe the curative effect of Lianhua Qingwen capsules on assisting chronic obstructive pulmonary disease(COPD) and its influence on lung function and inflammatory factors. Methods:A total of 100 COPD patients were randomly divided into the control group and the observation group,with 50 cases in each group. The control group received conventional symptomatic treatment,and the treatment group was assisted with Lianhua Qingwen capsules based on the treatment of the control group. After seven days of treatment, the clinical effects in the two groups were evaluated, and the Chinese medicine syndrome scores, lung function and levels of inflammatory factors in the two groups were compared before and after treatment. Results:The total effective rate was 88.00% in the treatment group, higher than that of 72.00% in the control group(P<0.05). When compared with those before treatment,the Chinese medicine syndrome scores and levels of serum interleukin-8(IL-8),interleukin-17 (IL-17) and tumor necrosis factor-α(TNF-α) in both groups were decreased after treatment(P<0.05). The percentage of forced expiratory volume in one second to predicted value(FEV1% ) and the percentage of forced vital capacity(FEV1/FVC) were increased(P<0.05). When compared with those in the control group after treatment, the Chinese medicine syndrome score and the levels of IL- 8, IL- 17 and TNF- α were lower in the treatment group after treatment(P<0.05),and the levels of FEV1% and FEV1/FVC were higher in the treatment group(P<0.05). Conclusion: Lianhua Qingwen capsules has a definite curative effect on assisting COPD,which is beneficial to alleviating clinical symptoms,improving lung function and inhibiting the release of inflammatory factors.

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虞鲁萍,陈春芳.连花清瘟胶囊辅助治疗慢性阻塞性肺疾病疗效及对肺功能、炎性因子的影响[J].新中医,2022,54(17):93-96

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  • 在线发布日期: 2022-09-06
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