麝香保心丸联合常规西药治疗心血瘀阻型冠心病心绞痛临床研究
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R541.4

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Clinical Study on Shexiang Baoxin Pills Combined with Routine Western Medicine for Angina Pectoris of Coronary Heart Disease of Heart Blood Stasis Obstruction Type
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    摘要:

    目的:观察麝香保心丸联合西药治疗心血瘀阻型冠心病心绞痛的疗效。方法:选取102 例心血瘀阻型冠心病心绞痛患者,按随机数字表法分为观察组和对照组各51 例。对照组给予常规西药治疗,观察组在对照组基础上加用麝香保心丸治疗。治疗3 个疗程后评估2 组临床疗效,比较2 组治疗前后心功能指标、血液流变学指标、脂代谢指标,统计不良反应发生率。结果:观察组总有效率为90.20%,高于对照组的74.51% (P<0.05)。治疗后, 2 组左室收缩末径(LVESD)、左室舒张末径(LVEDD)、QT 间期离散度(QTd) 较治疗前降低,左室射血分数(LVEF) 较治疗前升高(P<0.05);且观察组LVEF 高于对照组,LVESD、LVEDD、QTd 低于对照组(P<0.05)。治疗后,2 组高切全血黏度(HBV)、中切全血黏度(MBV)、低切全血黏度(LBV) 水平较治疗前降低(P<0.05);且观察组HBV、MBV、LBV 水平均低于对照组(P<0.05)。治疗后,2 组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(apoA)水平较治疗前降低(P<0.05);且观察组各项脂代谢指标均低于对照组(P<0.05)。结论:麝香保心丸联合常规西药治疗心血瘀阻型冠心病心绞痛的临床疗效显著,可改善患者的心功能、血液黏度和脂代谢指标。

    Abstract:

    Abstract: Objective: To observe the curative effect of Shexiang Baoxin Pill combined with western medicine in the treatment of angina pectoris of coronary heart disease with blood stasis type. Methods:A total of 102 patients with angina pectoris of coronary heart disease of heart blood stasis obstruction type were divided into the observation group and the control group according to the random number table method,with 51 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Shexiang Baoxin pills based on the treatment of the control group. After three courses of treatment, the clinical effects in the two groups were evaluated. Before and after treatment,the indexes of the heart function,hemorheology and lipid metabolism were compared, and the incidence of adverse reactions was counted. Results: The total effective rate of treatment in the observation group was 90.20%,which was higher than 74.51% in the control group(P< 0.05). After treatment, the LVESD, LVEDD and QTd of the two groups were lower than those before treatment, and the LVEF was higher than that before treatment(P<0.05). The LVEF of the observation group was higher than that of the control group,and the LVESD,LVEDD and QTd of the two groups were lower than those of the control group(P<0.05). After treatment,the levels of HBV,MBV and LBV in the two groups were lower than those before treatment(P<0.05),and the levels of HBV,MBV and LBV in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of TG, TC,LDL-C and apoA in the two groups were lower than those before treatment(P<0.05),and the blood lipid metabolism indexes in the observation group were lower than those in the control group(P<0.05). Conclusion:The therapy of Shexiang Baoxin pills combined with routine western medicine has a significant curative effect on angina pectoris of coronary heart disease of heart blood stasis obstruction type,which can improve the heart function and blood viscosity of patients and enhance their lipid metabolism.

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范钧,严春晓,周俊彦,刘叶,宓伟毅.麝香保心丸联合常规西药治疗心血瘀阻型冠心病心绞痛临床研究[J].新中医,2022,54(17):73-77

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  • 在线发布日期: 2022-09-06
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