Abstract：Objective：To observe the curative effect of Liujunzi tang and Xuanfu Daizhe tang combined with western medicine for reflux esophagitis and its effect on gastrointestinal hormone levels. Methods：A total of 84 cases of patients with reflux esophagitis were divided into the control group and the observation group according to the random number table method，with 42 cases in each group. The control group was treated with routine western medicine， and the observation group was additionally treated with Liujunzi tang and Xuanfu Daizhe tang based on the treatment of the control group. Clinical effects in the two groups were compared； Chinese medicine syndrome scores and gastrointestinal hormone levels including motilin， gastrin， somatostatin and cholecystokinin before and after treatment in the two groups were compared；the incidence of adverse reactions during treatment in the two groups was compared. Results： The total clinical effective rate was 90.48% in the observation group， higher than that of 73.81% in the control group(P＜0.05). After treatment，Chinese medicine syndrome scores and the levels of somatostatin and cholecystokinin in the two groups were decreased when compared with those before treatment(P＜ 0.05)， and the levels of motilin and gastrin were increased(P＜0.05)； Chinese medicine syndrome score and the levels of somatostatin and cholecystokinin in the observation group were lower than those in the control group(P＜0.05)，and the levels of motilin and gastrin were higher(P＜0.05). During treatment，the incidence of adverse reactions was 2.38% in the observation group and 4.76% in the control group，there being no significant difference between the two groups(P＞0.05). Conclusion：When compared with that of routine western medicine treatment，the therapy of Liujunzi tang and Xuanfu Daizhe tang combined with western medicine for patients with reflux esophagitis can enhance the clinical effect，accelerate the relief of symptoms and improve gastrointestinal hormone levels，with high safety.