六君子汤合旋覆代赭汤联合西药治疗反流性食管炎临床研究
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Clinical Study on Liujunzi Tang and Xuanfu Daizhe Tang Combined with Western Medicine for Reflux Esophagitis
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    摘要:

    目的:观察六君子汤合旋覆代赭汤联合西药治疗反流性食管炎的疗效及对胃肠激素水平的影响。方法:按照随机数字表法将84 例反流性食管炎患者分为对照组及观察组各42 例。对照组给予常规西药治疗,观察组在对照组基础上给予六君子汤合旋覆代赭汤治疗。比较2 组临床疗效,比较2 组治疗前后中医证候积分、胃动素、胃泌素、生长抑素、缩胆囊素等胃肠激素水平,并比较2 组治疗期间不良反应发生情况。结果:观察组临床总有效率90.48%,高于对照组73.81%(P<0.05)。与同组治疗前比较,治疗后2 组各中医证候积分及生长抑素、缩胆囊素水平均降低(P<0.05),胃动素、胃泌素水平均升高(P<0.05);与对照组治疗后比较,观察组治疗后各中医证候积分及生长抑素、缩胆囊素水平均较低(P<0.05),胃动素、胃泌素水平均较高(P<0.05)。治疗期间,观察组不良反应发生率2.38%,对照组为4.76%,2 组比较,差异无统计学意义(P>0.05)。结论:相比于常规西药治疗,六君子汤合旋覆代赭汤联合西药治疗反流性食管炎患者可提高临床疗效,加快症状缓解,改善胃肠激素水平,且安全性较高。

    Abstract:

    Abstract:Objective:To observe the curative effect of Liujunzi tang and Xuanfu Daizhe tang combined with western medicine for reflux esophagitis and its effect on gastrointestinal hormone levels. Methods:A total of 84 cases of patients with reflux esophagitis were divided into the control group and the observation group according to the random number table method,with 42 cases in each group. The control group was treated with routine western medicine, and the observation group was additionally treated with Liujunzi tang and Xuanfu Daizhe tang based on the treatment of the control group. Clinical effects in the two groups were compared; Chinese medicine syndrome scores and gastrointestinal hormone levels including motilin, gastrin, somatostatin and cholecystokinin before and after treatment in the two groups were compared;the incidence of adverse reactions during treatment in the two groups was compared. Results: The total clinical effective rate was 90.48% in the observation group, higher than that of 73.81% in the control group(P<0.05). After treatment,Chinese medicine syndrome scores and the levels of somatostatin and cholecystokinin in the two groups were decreased when compared with those before treatment(P< 0.05), and the levels of motilin and gastrin were increased(P<0.05); Chinese medicine syndrome score and the levels of somatostatin and cholecystokinin in the observation group were lower than those in the control group(P<0.05),and the levels of motilin and gastrin were higher(P<0.05). During treatment,the incidence of adverse reactions was 2.38% in the observation group and 4.76% in the control group,there being no significant difference between the two groups(P>0.05). Conclusion:When compared with that of routine western medicine treatment,the therapy of Liujunzi tang and Xuanfu Daizhe tang combined with western medicine for patients with reflux esophagitis can enhance the clinical effect,accelerate the relief of symptoms and improve gastrointestinal hormone levels,with high safety.

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张皓,孙艺铭,魏春芬.六君子汤合旋覆代赭汤联合西药治疗反流性食管炎临床研究[J].新中医,2022,54(17):69-72

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  • 在线发布日期: 2022-09-06
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