补肾活血汤联合塞来昔布胶囊治疗膝骨关节炎临床研究
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R684.3

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Clinical Study on Bushen Huoxue Tang and Celecoxib Capsules in treatment of Knee Osteoarthritis
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    摘要:

    目的:观察补肾活血汤联合塞来昔布胶囊治疗膝骨关节炎(KOA) 的临床疗效及对西安大略和麦克马斯特大学骨关节炎指数可视化量表(WOMAC) 及生活质量测评量表简表(SF-36) 评分的影响。方法:将120 例KOA 患者分为2 组,对照组60 例采用塞来昔布胶囊治疗,治疗组60 例在对照组基础上联合补肾活血汤治疗。比较2 组治疗前后膝关节Lysholm 功能、视觉模拟评分法(VAS)、WOMAC、SF-36 评分及各炎症指标变化,并比较2 组临床疗效和不良反应。结果:治疗组治疗总有效率96.67%,高于对照组85.00% (P<0.05)。与同组治疗前比较,治疗后2 组WOMAC、VAS 评分及肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β)、白细胞介素-6 (IL-6) 水平均降低(P<0.05),SF-36、膝关节Lysholm 功能评分均升高(P<0.05);与对照组治疗后比较,治疗组治疗后WOMAC、VAS 评分及IL-1β、TNF-α、IL-6 水平均较低(P<0.05),SF-36、膝关节Lysholm 功能评分均较高(P<0.05)。结论:补肾活血汤联合塞来昔布胶囊治疗KOA 临床疗效较佳,不但可缓解疼痛,提高膝关节功能和生活质量,还能减轻炎症反应,且安全性好。

    Abstract:

    Abstract:Objective:To observe the curative effect of the therapy of Bushen Huoxue tang combined with celecoxib capsules on knee osteoarthritis(KOA) and its effect on the scores of Western Ontario and McMaster Universities Arthritis Index(WOMAC) and 36-Item Short Form Health Survey(SF- 36). Methods: A total of 120 KOA patients were divided into two groups. The control group(60 cases) was given with celecoxib capsules,and the treatment group(60 cases) was given with Bushen Huoxue tang based on the treatment of the control group. The changes of scores of Lysholm scale for function of knee joint,Visual Analogue Scale(VAS), WOMAC and SF- 36 and inflammatory markers were compared between the two groups, and the clinical effects and adverse reactions were compared in two groups. Results: The total effective rate was 96.67% in the treatment group,which was higher when compared with that of 85.00% in the control group(P<0.05). The scores of WOMAC and VAS and levels of tumor necrosis factor-α(TNF-α), interleukin- 1β(IL- 1β) and interleukin- 6(IL- 6) in the two groups were decreased after treatment when compared with those in the same group before treatment(P<0.05),and the scores of SF-36 and Lysholm scale were increased(P<0.05); after treatment, the scores of WOMAC and VAS and levels of IL- 1β, TNF-α and IL-6 in treatment group were lower when compared with those in control group(P<0.05),and the scores of SF- 36 and Lysholm scale in the treatment group were higher(P<0.05). Conclusion: The therapy of Bushen Huoxue tang combined with celecoxib capsules can improve the clinical effect on KOA, relieve the pain, improve the knee joint function and quality of life, and reduce the inflammatory responses,with good safety.

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张志远,张跃正.补肾活血汤联合塞来昔布胶囊治疗膝骨关节炎临床研究[J].新中医,2022,54(17):61-64

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  • 在线发布日期: 2022-09-06
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