Abstract： Objective： To observe the clinical effect of modified Banxia Houpu tang combined with acupuncture for gastroesophageal reflux disease of phlegm- qi depression type. Methods ： A total of 60 cases of patients with gastroesophageal reflux disease of phlegm-qi depression type were selected as the study objects， and were divided into the observation group and the control group according to the random number table method， with 30 cases in each group. The control group was treated with routine western medicine，and the observation group was treated with modified Banxia Houpu tang combined with acupuncture. Chinese medicine syndrome scores and mRNA expression levels of cyclooxygenase-2(COX-2) and protease activated receptor- 2(PAR- 2) in esophageal mucosa before and after treatment as well as clinical effects in the two groups were compared. Results： The total effective rate was 93.3% in the observation group， higher than that of 70.0% in the control group， the difference being significant(P＜ 0.05). Before treatment，there were no significant difference being found in the comparison of the scores of chest oppression，pharyngeal burning，acid reflux and belching and sighing between the two groups(P＞ 0.05). After treatment，the scores of chest oppression，pharyngeal burning，acid reflux and belching and sighing in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the observation group were lower than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of mRNA expressions of COX-2 and PAR-2 in esophageal mucosa between the two groups(P＞0.05). After treatment，the mRNA expressions of COX- 2 and PAR- 2 in the two groups were decreased when compared with those before treatment， and the mRNA expressions of COX- 2 and PAR- 2 in the observation group were lower than those in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of modified Banxia Houpu tang combined with acupuncture for gastroesophageal reflux disease of phlegm- qi depression type has a good curative effect， which can improve the Chinese medicine syndromes of patients and reduce the mRNA expressions of COX-2 and PAR-2 in esophageal mucosa.