Abstract：Objective：To systematically evaluate the clinical effect and safety of integrated Chinese and western medicine for ventilator- associated pneumonia(VAP). Methods： Randomized controlled trials of integrated Chinese and western medicine for VAP were searched in databases of CNKI，WanFang，VIP， sinoMed， PubMed， Embase and Cochrane Library. Two researchers conducted literature screening and data extraction according to inclusion and exclusion criteria. RenMan 5.4 software， TSA0.9.5.10 Beta software and Stata15.0 software were applied for meta analysis of the included studies. Results：A total of 24 studies were included，involving 1 636 cases of patients，with 834 cases in the experiment group and 802 cases in the control group. Meta analysis showed that the improvement of the total effective rate [OR= 3.02，95%CI (2.19，4.15），P＜0.000 01] and the offline rate [OR=2.08，95%CI(1.13，3.81），P=0.02]， the shortening of the length of ICU stay [MD=- 3.59， 95% CI (- 4.50， - 2.68）， P＜0.000 01] and the duration of mechanical ventilation [MD=- 2.62， 95%CI (- 2.89， - 2.34）， P＜0.000 01]， as well as the reduction of fatality rate [OR=0.33，95%CI (0.17，0.66），P=0.002]，Acute Physiology and Chronic Health EraluationⅡscore (APACHE Ⅱ) scores [MD=- 3.98，95%CI (- 6.87， - 1.09）， P=0.007] and C- reactive protein(CRP) [MD=- 14.19， 95% CI (- 19.76， - 8.62）， P＜0.000 01] in the experiment group were superior to those in the control group. No serious adverse reactions were found in the experiment group. The trial sequential analysis showed that the clinical effect of integrated Chinese and western medicine for VAP was better. Conclusion： Integrated Chinese and western medicine has a better curative effect and higher safety than simple western medicine in the treatment of VAP.