Abstract： This paper summarizes the clinical experience of Professor LIU Maocai in syndrome differentiation and treatment of epilepsy by differentiating yin，yang，deficiency and excess. Pro. LIU holds that the etiology of epilepsy is rooted at deficiency， with wind， phlegm， fire and blood stasis as branches，and "lingering and congealing phlegm" as the core pathological factor. In clinical practice，staging syndrome differentiation and treatment should be carried out according to the primary and secondary contradictions. In the acute stage，yin and yang are the key points；yang epilepsy belongs to wind-fire and phlegm- heat， which can be treated by clearing heat and purging fire， calming the liver and extinguish wind，and clearing up phlegm and resuscitating，and the hospital preparation，Tongfu Xingshen capsules made by Pro. LIU will be useful. Yin epilepsy belongs to phlegm- stasis due to deficiency- cold；it can be treated by warming and dissolving cold-phlegm，extinguish wind and invigorating blood，and opening the orifices to awaken the mind，and the hospital preparation，Yinao’an capsules made by Pro. LIU is a choice for the treatment. In the remission period， after the differentiation between deficiency and excess， the heart and liver should be treated if there is excess，and the spleen and kidney should be supplemented if there is deficiency. Tongfu Xingshen capsules can be used in the acute phase of yang epilepsy， while Yinaoan capsules can be used in the treatment of yin epilepsy or the remission period of epilepsy. In terms of prescription and medication， insect medicinals should be used flexibly， and it is emphasized that the medication should be neutral and avoid toxicity，and attention should be paid to protecting the foundation and the spleen and stomach at all times.