Abstract：Through the analysis of the physiological characteristics，physiological function，course of channels and collaterals and the relationship between the spleen and muscle，this paper emphasizes the importance of muscle tissue in the occurrence and development of knee osteoarthritis，and believes that knee osteoarthritis has pathological changes of both muscle and bone， which can be treated with the simultaneous treatment of muscle and bone. The specific simultaneous treatment of muscle and bone is the spleen-fortifying method.