穴位贴敷联合低频重复经颅磁刺激治疗男性血管性痴呆临床研究
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Clinical Study on Point Application Combined with Low- Frequency Repetitive Transcranial Magnetic Stimulation for Male Vascular Dementia
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    摘要:

    目的:观察穴位贴敷联合低频重复经颅磁刺激治疗男性血管性痴呆(VD) 的临床疗效,以及对患者抗氧化指标及血管内皮功能的影响。方法:选取80 例男性VD 患者,随机分为联合组和对照组各40 例。2 组均给予尼莫地平治疗,对照组在此基础上使用低频重复经颅磁刺激治疗,联合组在对照组基础上加用穴位贴敷治疗,2 组均治疗12 周。比较2 组临床疗效与治疗前后抗氧化指标[谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)]、血管内皮功能指标[血管内皮生长因子(VEGF)、内皮素-1(ET-1)、一氧化氮(NO)]水平,以及简易智力状态检查量表(MMSE)、日常生活能力量表(ADL) 评分。结果:联合组总有效率95.00%,高于对照组80.00%(P<0.05)。治疗后,2 组GSH-Px、SOD、VEGF、NO 水平均较治疗前升高(P<0.05),MDA、ET-1 水平均较治疗前降低(P<0.05);联合组GSH-Px、SOD、VEGF、NO 水平均高于对照组(P<0.05),MDA、ET-1 水平均低于对照组(P<0.05)。治疗后,2 组MMSE、ADL 评分均较治疗前升高(P<0.05),联合组MMSE、ADL 评分均高于对照组(P<0.05)。结论:穴位贴敷联合低频重复经颅磁刺激治疗男性VD 临床疗效确切,能够改善患者的抗氧化指标及血管内皮功能,提高其认知功能和生活自理能力。

    Abstract:

    Abstract: Objective: To observe the clinical effect of the therapy of point application combined with low- frequency repetitive transcranial magnetic stimulation on male patients with vascular dementia (VD), and its effect on antioxidant indexes and vascular endothelial function. Methods:A total of 80 male patients with VD were randomly divided into the combination group and the control group,with 40 cases in each group. Both groups were treated with nimodipine, the control group was additionally treated with lowfrequency repetitive transcranial magnetic stimulation,and the combination group was additionally treated with point application based on the treatment of the control group. Both groups were treated for twelve weeks. The clinical effect and levels of antioxidant indexes, including glutathione peroxidase(GSH- Px), malondialdehyde(MDA) and superoxide dismutase(SOD), and vascular endothelial function indexes, including vascular endothelial growth factor(VEGF), endothelin- 1(ET- 1) and nitric oxide(NO), and the scores of Mini-mental State Examination and Activity of Daily Living(ADL) before and after treatment were compared between the two groups. Results: The total effective rate was 95.00% in the combination group,higher than that of 80.00% in the control group(P<0.05). After treatment,the levels of GSH-Px, SOD,VEGF and NO in both groups were increased when compared with those before treatment(P<0.05), and the levels of MDA and ET-1 were decreased(P<0.05);the levels of GSH-Px,SOD,VEGF and NO in the combination group were higher than those in the control group(P<0.05), and the levels of MDA and ET- 1 were lower(P<0.05). After treatment, the MMSE and ADL scores in both groups were increased when compared with those before treatment(P<0.05),and the MMSE and ADL scores in the combination group were higher than those in the control group(P<0.05). Conclusion: The therapy of point application combined with low- frequency repetitive transcranial magnetic stimulation has a definite clinical effect on male VD patients,which can improve antioxidant indexes and vascular endothelial function,and enhance their cognitive function and activity of daily living.

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周妙珍.穴位贴敷联合低频重复经颅磁刺激治疗男性血管性痴呆临床研究[J].新中医,2022,54(16):171-174

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  • 在线发布日期: 2022-08-28
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