Abstract： Objective： To observe the clinical effect of the therapy of point application combined with low- frequency repetitive transcranial magnetic stimulation on male patients with vascular dementia (VD)， and its effect on antioxidant indexes and vascular endothelial function. Methods：A total of 80 male patients with VD were randomly divided into the combination group and the control group，with 40 cases in each group. Both groups were treated with nimodipine， the control group was additionally treated with lowfrequency repetitive transcranial magnetic stimulation，and the combination group was additionally treated with point application based on the treatment of the control group. Both groups were treated for twelve weeks. The clinical effect and levels of antioxidant indexes， including glutathione peroxidase(GSH- Px)， malondialdehyde(MDA) and superoxide dismutase(SOD)， and vascular endothelial function indexes， including vascular endothelial growth factor(VEGF)， endothelin- 1(ET- 1) and nitric oxide(NO)， and the scores of Mini-mental State Examination and Activity of Daily Living(ADL) before and after treatment were compared between the two groups. Results： The total effective rate was 95.00% in the combination group，higher than that of 80.00% in the control group(P＜0.05). After treatment，the levels of GSH-Px， SOD，VEGF and NO in both groups were increased when compared with those before treatment(P＜0.05)， and the levels of MDA and ET-1 were decreased(P＜0.05)；the levels of GSH-Px，SOD，VEGF and NO in the combination group were higher than those in the control group(P＜0.05)， and the levels of MDA and ET- 1 were lower(P＜0.05). After treatment， the MMSE and ADL scores in both groups were increased when compared with those before treatment(P＜0.05)，and the MMSE and ADL scores in the combination group were higher than those in the control group(P＜0.05). Conclusion： The therapy of point application combined with low- frequency repetitive transcranial magnetic stimulation has a definite clinical effect on male VD patients，which can improve antioxidant indexes and vascular endothelial function，and enhance their cognitive function and activity of daily living.