Abstract：Objective：To observe the clinical effect of Sanqi Jiegu pills combined with internal fixation with hollow screw for femoral neck fracture in the senile. Methods：A total of 112 cases of senile patients with femoral neck fracture were selected and divided into the study group and the control group according to the random number table method， with 56 cases in each group respectively， 6 cases were excluded from the study group， 50 cases were left. Both groups were treated with internal fixation with hollow screw. After surgery，the control group was routinely treated with analgesia，anti-infection and prevention of osteoporosis，and the study group was additionally treated with Sanqi Jiegu pills based on the treatment of the control group. The clinical effects and the incidence of complications in the two groups were compared. Before and after treatment， the levels of insulin- like growth factor- 1(IGF- 1)， vascular endothelial growth factor(VEGF) and bone morphogenetic protein-2(BMP-2) as well as the Harris scores in the two groups were compared. Results： The total effective rate was 96.0% in the study group， higher than that of 87.5% in the control group(P＜0.05). After treatment，the levels of VEGF，BMP-2 and IGF-1 as well as the Harris scores in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of VEGF，BMP-2 and IGF-1 as well as the Harris score in the study group were higher than those in the control group(P＜0.05). The total incidence of complications was 10.0% in the study group， lower than that of 21.4% in the control group(P＜0.05). Conclusion： After internal fixation with hollow screw， the treatment of Sanqi Jiegu pills for senile patients with femoral neck fracture can effectively improve their hip joint function and bone healing， and reduce the incidence of complications after surgery.