Abstract: Objective: To observe the clinical effect of the therapy of Tongbi Qiangxin tang combined with trimetazidine on angina pectoris of coronary heart disease. Methods: A total of 102 patients with angina pectoris of coronary heart disease were selected and divided into two groups according to the random number table method, with 51 cases in each group. The control group was treated with trimetazidine dihydrochloride tablets, and the observation group was additionally treated with Tongbi Qiangxin tang based on the treatment of the control group. Both groups were treated for two weeks. The clinical effects, attacks of angina pectoris and indexes of blood lipid were compared between the two groups. Results:The total effective rate was 94.12% in the observation group,higher than that of 80.39% in the control group(P<0.05). After treatment,the number of attacks of angina pectoris in the two groups were decreased when compared with those before treatment, and which in the observation group was less than in the control group(P<0.05);the duration of angina pectoris were shortened,and which in the observation gruop was shorter in the control group(P<0.05). After treatment,the levels of total cholesterol (TC), low- density lipoprotein cholesterol(LDL- C) and triglyceride(TG) in the two groups were decreased when compared with those before treatment,and which in the observation group were lower than those in the control group(P<0.05); the level of high- density lipoprotein cholesterol(HDL- C) in the tow groups were increased when compared before treatemtn, and which in the observation group was higher(P< 0.05). Conclusion: The therapy of Tongbi Qiangxin tang combined with trimetazidine for patients with angina pectoris of coronary heart disease can reduce the number of attacks of angina pectoris,shorten the duration of angina pectoris,and improve the levels of blood lipid.