Abstract：Objective：To observe the clinical effect of the therapy of Shenmai injection combined with bisoprolol on acute exacerbation of chronic pulmonary heart disease(CPHD). Methods：A total of 76 patients with acute exacerbation of CPHD were selected and divided into the control group and the observation group according to the random number table method，with 38 cases in each group. The control group was treated with bisoprolol，and the observation group was additionally treated with Shenmai injection based on the treatment of the control group. Both groups were treated for 14 days. The clinical effects and incidence of complications were compared between the two groups；before and after treatment，the classification of the lung function and heart function and levels of inflammatory factors and N-terminal pro-brain natriuretic peptide(NT- proBNP) were compared between the two groups. Results： The total effective rate was 86.84% in the observation group，higher than that of 63.16% in the control group(P＜0.05). After treatment， the levels of pulmonary artery pressure(PAP) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of forced expiratory volume in one second(FEV1) and forced vital capacity(FVC) were increased(P＜0.05)；the level of PAP in the observation group was lower than that in the control group(P＜0.05)，and the levels of FEV1 and FVC in the observation group were higher(P＜0.05). After treatment，the grading of heart function according to New York Heart Association(NYHA) in the two groups was improved when respectively compared with that before treatment(P＜0.05)， and the grading in the observation group was better than that in the control group(P＜0.05). After treatment，the levels of serum NT-proBNP，tumor necrosis factor- α(TNF-α) and interleukin- 6(IL-6) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three levels in the observation group were lower than those in the control group(P＜0.05). The incidence of complications was 15.78% in the observation group，lower than that of 39.47% in the control group. Conclusion：The therapy of Shenmai injection combined with bisoprolol has a good curative effect on acute exacerbation of CPHD， which can effectively reduce the levels of PAP and NT- proBNP， enhance the heart and lung function， inhibit the inflammatory responses，and reduce the incidence of complications.