Abstract： Objective： To observe the clinical effect of Modified Xuefu Zhuyu Tang Combined with Bilateral Decompressive Craniotomy for severe contrecoup contusion and laceration of brain. Methods： A total of 70 cases of patients with severe contrecoup contusion and laceration of brain were selected and divided into the observation group and the control group according to the random number table method， with 35 cases in each group. Based on routine western medicine treatment， the control group was treated with bilateral decompressive craniotomy， and the observation group was additionally treated with modified Xuefu Zhuyu tang based on the treatment of the control group. Both groups were treated for 14 days. The intracranial pressure before treatment and 1 and 14 days after treatment， and the changes in Glasgow Coma index(GCS) scores before treatment and 14 days after treatment in the two groups were observed. Incidence of complications in the two groups during treatment was counted. Results： Before treatment， there was no significant difference being found in the comparison of the levels of intracranial pressure between the two groups(P＞0.05). After 1 and 14 days of treatment， intracranial pressure in the two groups was significantly decreased when compared with that before treatment(P＜0.05)， and intracranial pressure in the observation group was lower than that in the control group at the same treatment time points (P＜0.05). Before treatment， there was no significant difference being found in the comparison of GCS scores between the two groups(P＞0.05). After 14 days of treatment， GCS scores in the two groups were increased when compared with those before treatment(P＜0.05)， and GCS score in the observation group was higher than that in the control group(P＜0.05). The incidence of complications was 8.57% in the observation group and 28.57% in the control group， the difference being significant(P＜0.05). Conclusion： Modified Xuefu Zhuyu Tang Combined with Bilateral Decompressive Craniotomy for severe contrecoup contusion and laceration of brain can effectively reduce intracranial pressure and the incidence of postoperative complications， and improve coma degree.