Abstract： Objective： To explore and analyze Prof. YANG Nizhi's administration experience， administration rule and prescription characteristics in treating primary nephrotic syndrome through data mining of the medical records of primary nephrotic syndrome. Methods：A total of 111 cases of outpatient medical records were collected， involving 307 visits. Medical records were transformed into texts； data files were established；data were analyzed through the system software of Famous Physicians’Inheritance Platform，and Prof. YANG’s administration experience and prescription rules were summarized. Results： The statistics of herbs used showed that the top 17 core herbs with high frequency were Radix et Rhizoma Glycyrrhizae， Limonitum， Radix Astragali， Semen Persicae， Radix et Rhizoma Salviae Miltiorrhizae， Fructus Ligustri Lucidi， Radix Rehmanniae Praeparata， Herba Taraxaci， Folium Pyrrosiae， Semen Cuscutae， Fructus Corni， Herba Ecliptae， Rhizoma Atractylodis Macrocephalae， Radix Paeoniae Alba， Radix Pseudostellariae，Rhizoma Smilacis Glabrae and Radix Angelicae Sinensis. Clinical commonly- used Chinese herbal combination included： Fructus Corni- Semen Cuscutae， Fructus Rubi- Fructus Rosae Laevigatae，Semen Ziziphi Spinosae-Cortex Albiziae，and Radix Astragali-Herba Lycopi-Semen Persicae. Conclusion：In the experience of Prof. YANG in differentiating primary nephrotic syndrome，the syndrome type is mainly qi deficiency and blood stasis，and the method of boosting qi and invigorating blood or the method combining the method of promoting urination are the main treatment methods. Core herbs and herbal pairs that particularly treat the disease are obtained，and his prescriptions mainly consist of neutral herbs. Prof. YANG uses herbs concisely but the effects of them are particular.