Abstract： Objective： To observe the curative effect of Tiangou Shixi tang combined with routine western medicine for ischemic stroke and its effects on serum indexes. Methods：A total of 200 cases of patients with ischemic stroke were selected as the study objects and divided into the control group and the observation group according to the random number table method， with 100 cases in each group. Both groups were given symptomatic treatment after admission；the control group was given intravenous drip with edaravone injection， and the observation group was additionally treated with modified Tiangou Shixi tang based on the treatment of the control group. The scores of National Institutes of Health Stroke Scale (NIHSS) and Barthel Index(BI) were compared between the two groups before and after treatment，and the levels of regulatory T cells(Treg)， helper T cells 17(Th17)， Th17/Treg， vascular endothelial growth factor (VEGF) and angiopoietin-2(Ang-2) in peripheral blood were detected. Results：The total effective rate was 95.00% in the observation group， higher than that of 71.00% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of NIHSS and BI between the two groups(P＞0.05). After treatment， NIHSS scores in the two groups were decreased when compared with those before treatment，and BI scores were increased(P＜ 0.05)；NIHSS score in the observation group was lower than that in the control group，and BI score was higher(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of Treg，Th17 and Th17/Treg between the two groups(P＞0.05). After treatment，Treg levels in the two groups were increased when compared with those before treatment，and levels of Th17 and Th17/Treg were decreased(P＜0.05)； Treg level in the observation group was higher than that in the control group， and levels of Th17 and Th17/Treg were lower(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of VEGF and Ang- 2 between the two groups(P＞0.05). After treatment，levels of VEGF and Ang-2 in the two groups were increased when compared with those before treatment(P＜0.05)， and the two levels in the observation group were higher than those in the control group(P＜0.05). Conclusion： Tiangou Shixi tang combined with routine western medicine has an ideal curative effect in the treatment of ischemic stroke. It can effectively improve the neurological function and daily activity of patients，and its mechanism may be related to the regulation of levels of Th17/Treg， VEGF and Ang-1.