Abstract：Objective：To observe the clinical effect of the therapy of modified Danzhi Xiaoyao powder combined with Betaloc on cardiac neurosis with syndrome of binding constraint of liver qi and its safety. Methods：A total of 90 patients with cardiac neurosis with syndrome of binding constraint of liver qi were randomly divided into the control group and the observation group，with 45 cases in each group. The control group was treated with Betaloc，and the observation group was additionally treated with modified Danzhi Xiaoyao powder based on the treatment of the control group. The scores of Chinese medicine syndromes， scores of Hospital Anxiety and Depression Scale(HADS)，24 h heart rate and premature beats before and after treatment were compared between the two groups，and the incidence of adverse medicine reactions during treatment was compared. Results：Compared with those in the same group before treatment，the scores of Chinese medicine syndromes in both groups， such as palpitation， shortness of breath， chest oppression，insomnia and fatigue，the scores of anxiety and depression in HADS，24 h heart rate and 24 h premature beats in the observation group were decreased after treatment(P＜0.05). Compared with those in the control group after treatment， the scores of the above Chinese medicine syndromes， the scores of anxiety and depression in HADS，24 h heart rate and 24 h premature beats were lower in the observation group after treatment(P＜0.05). There was no significant difference in the comparison of adverse reactions between the two groups(P＞0.05). Conclusion：The therapy of modified Danzhi Xiaoyao powder combined with Betaloc has a significant therapeutic effect on cardiac neurosis with syndrome of binding constraint of liver qi，which helps relieve the anxiety and depression of patients，with great safety.