桃红四物汤联合布洛芬缓释胶囊治疗子宫腺肌症临床研究
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R711.74

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Clinical Study on Taohong Siwu Tang Combined with Ibuprofen Sustained Release Capsules for Adenomyosis
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    摘要:

    目的:观察桃红四物汤联合布洛芬缓释胶囊在子宫腺肌症中的应用效果及对子宫血流参数的影响。方法:选取72 例子宫腺肌症患者为研究对象,按随机数字表法分为对照组和观察组各36 例。对照组给予布洛芬缓释胶囊口服,观察组在对照组基础上加用桃红四物汤治疗。比较2 组临床疗效、治疗前后的疼痛程度、血清前列腺素、糖类抗原125(CA125) 与子宫血流参数。结果:观察组总有效率为100%,高于对照组86.11%,差异有统计学意义(P<0.05)。治疗1 个疗程、3 个疗程后,2 组视觉模拟评分法(VAS) 评分逐渐降低,且观察组VAS 评分均低于同时间点对照组,差异均有统计学意义(P<0.05)。治疗1 个疗程、治疗3 个疗程后,2 组血清前列腺素及CA125 水平逐渐降低,且观察组血清前列腺素及CA125 水平均低于同时间点对照组,差异均有统计学意义(P<0.05)。治疗1 个疗程、治疗3 个疗程后,2 组子宫动脉收缩期峰值血流速度(PSV)、舒张期峰值血流速度(EDV) 逐渐降低,阻力指数(RI) 逐渐升高(P<0.05);且观察组PSV、EDV 均低于同时间点对照组,RI 高于同时间点对照组(P<0.05)。结论:桃红四物汤联合布洛芬缓释胶囊治疗子宫腺肌症临床疗效较好,可以减轻疼痛,降低血清前列腺素及CA125 水平,改善子宫动脉血流参数。

    Abstract:

    Abstract:Objective:To observe the application effect of Taohong Siwu tang combined with ibuprofen sustained release capsules on adenomyosis and its effect on uterine blood flow parameters. Methods: A total of 72 patients with adenomyosis were selected as the research objects and divided into the control group and the observation group according to the random number table method, with 36 cases in each group. The control group was given ibuprofen sustained-release capsules orally,and the observation group was additionally treated with Taohong Siwu tang based on the treatment of the control group. The clinical effects and the degrees of pain,serum prostaglandin,carbohydrate antigen 125(CA125) and uterine blood flow parameters before and after treatment were compared between the two groups. Results: The total effective rate was 100% in the observation group, higher than that of 86.11% in the control group, the difference being significant (P<0.05). After one course and three courses of treatment,the scores of Visual Analogue Scale(VAS) in the two groups were decreased gradually,and the scores of VAS in the observation group were lower than those in the control group at the same time respectively, differences being significant(P<0.05). After one course and three courses of treatment, the levels of serum prostaglandin and CA125 in the two groups were decreased gradually,and the above two levels in the observation group were lower than those in the control group at the same time respectively,differences being significant(P< 0.05). After one course and three courses of treatment,the levels of peak systolic velocity(PSV) and enddiastolic velocity(EDV) during systolic period of uterine arteries in the two groups were decreased gradually, and the levels of resistance index (RI) were gradually increased(P<0.05);the levels of PSV and EDV in the observation group were lower than those in the control group at the same time respectively,and the levels of RI in the study group were higher(P<0.05). Conclusion: The therapy of Taohong Siwu tang combined with ibuprofen sustained release capsules has a good clinical effect on adenomyosis,which can relieve the pain,reduce the levels of serum prostaglandin and CA125,and improve the uterine blood flow parameters.

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周园园,张静,童乃云.桃红四物汤联合布洛芬缓释胶囊治疗子宫腺肌症临床研究[J].新中医,2022,54(15):41-44

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  • 在线发布日期: 2022-08-04
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