Abstract： Objective： To observe the clinical effect of point application with Zengye Maren tang combined with mosapride for constipation after craniocerebral trauma. Methods：A total of 86 patients with constipation after craniocerebral trauma were selected and divided into the control group and the observation group according to the random number table method，with 43 cases in each group. The control group was treated with mosapride citrate tablets， and the observation group was additionally treated with point application with Zengye Maren tang based on the treatment of the control group. Both groups were treated for two weeks. The degree of constipation and the levels of inflammatory factors in serum before and after treatment，as well as the clinical effects and the incidence of adverse reactions in the two groups were compared. Results：The total effective rate was 95.35% in the observation group，higher than that of 81.40% in the control group(P＜0.05). After treatment，the scores of Cleveland Constipation Score(CCS) and Patient Assessment of Constipation Symptoms(PAC-SYM) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores of CCS and PAC-SYM in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of C-reactive protein (CRP)， interleukin- 1β(IL- 1β) and tumor necrosis factor- α(TNF- α) in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of CRP， IL-1β and TNF- α in serum in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 9.30% in the observation group and 4.65% in the control group，there being no significance in the difference(P＞0.05). Conclusion： Point application with Zengye Maren tang combined with mosapride for constipation after craniocerebral trauma can significantly improve the symptom of constipation and decrease levels of inflammatory factors in serum，with good clinical effect and safety.