Abstract： Objectives： To analyze the Chinese medicine administration experience and prescription rules of Chinese medicine for acute exacerbation of chronic cor pulmonale heart disease based on Traditional Chinese Medicine Inheritance Support System(V2.5). Methods： Literature related to acute exacerbation of chronic cor pulmonale heart disease published from January 1，2010 to June 15，2021 were searched，and the prescriptions were extracted to establish a database. Administration experience and prescription rules were analyzed by association rule analysis，improved mutual information，complex system entropy clustering on Traditional Chinese Medicine Inheritance Support System. Results：A total of 313 prescriptions were imput，involving 160 kinds of Chinese medicine. There were 24 kinds of Chinese medicine with a usage frequency of more than 55 times，and the top five were Radix Astragali，Poria， Rhizoma Atractylodis Macrocephalae， Radix et Rhizoma Salviae Miltiorrhizae， and Semen Lepidii. According to the analysis of the dosage of the top five Chinese medicines，the common dosage of Radix Astragali， Poria， Rhizoma Atractylodis Macrocephalae， Radix et Rhizoma Salviae Miltiorrhizae， and Semen Lepidii were 30 g，15 g，15 g，30 g and 20 g respectively. There were 29 groups of Chinese medicine combinations with a usage frequency of more than 50 times，and the top five combinations were Rhizoma Atractylodis Macrocephalae- Poria， Radix Astragali- Poria， Radix et Rhizoma Salviae Miltiorrhizae- Poria， Radix et Rhizoma Salviae Miltiorrhizae- Radix Astragali， and Ramulus Cinnamomi- Poria. A total of 20 core combinations and 10 new prescriptions were evolved. Conclusion： Chinese medicine for acute exacerbation of chronic cor pulmonale heart disease is characterized by “healthy qi deficiency，static blood，phlegm turbidity，and retained fluid”，and “boosting qi and activating blood as the main treatment，resolving phlegm and expelling water as a supplement” is the fundamental treatment.