Abstract： Objective： To study and analyze the molecular mechanism of Wuda granules for gastrointestinal motility disorder(GMD) through network pharmacology and molecular docking technology. Methods：The effective components and the action targets of Wuda granules were collected by Traditional Chinese Medicine Systems Pharmacology and Analysis Platform(TCMSP)； the targets related to gastrointestinal motility disorder were collected by GeneCards and OMIM databases；the “component- target” network was constructed by Cytoscape software；the target protein PPI network was constructed by STRING database；the key targets were given GO biological function annotation and KEGG pathway analysis；the core active components of Wuda granules and the core targets of gastrointestinal motility disorder were given molecular docking by AutoDockTools software. Results：The “component-target” network showed that the core active components of Wuda granules were quercetin， β- sitosterol， stigmasterol and kaempferol；PPI network showed that proteins like JUN，IL-6 and FOS had significant effects；GO was enriched in signal transduction，inflammatory responses and immune responses，etc.； KEGG pathway was enriched in TNF and IL-17 signaling pathways；the molecular docking results showed that the core active components and the core targets had good binding activity. Conclusion： The mechanism of Wuda granules in the treatment of GMD may be that quercetin，β-sitosterol，stigmasterol and kaempferol act on JUN，IL-6 and FOS to regulate signal transduction，inflammatory responses and immune responses.