Abstract： Objective： To observe the clinical effect of Tongfu Jiedu tang combined with western medicine for malignancy intestinal obstruction and its effect on inflammatory factors. Methods：A total of 106 cases of patients with malignancy intestinal obstruction were randomly divided into the control group and the experiment group according to the random number table method，with 53 cases in each group. The control group was treated with routine western medicine， and the experiment group was additionally treated with Tongfu Jiedu tang based on the treatment of the control group. Karnofsky Performance Status (KPS) scores， Chinese medicine syndrome scores and inflammatory factor levels before and after treatment， and the clinical effects and adverse reactions in the two groups were evaluated. in the two groups were compared. Results：The total effective rate was 94.34% in the experiment group and 77.36% in the control group， the difference being significant(P＜0.05). After treatment， KPS scores in the two groups were increased when compared with those before treatment(P＜0.05)， and the KPS score in the experiment group was higher than that in the control group(P＜0.05). After treatment， Chinese medicine syndrome scores and the levels of endotoxin(ET)， interleukin- 6(IL- 6)， procalcitonin(PCT)， C- reactive protein(CRP) and tumor necrosis factor-α(TNF-α) in the two groups were lower than those before treatment (P＜0.05)；the Chinese medicine syndrome score and the levels of inflammatory factors in the experiment group were lower than those in the control group(P＜0.05). There was no obvious adverse drug reaction in the two groups. Conclusion： The therapy of Tongfu Jiedu tang combined with western medicine for malignancy intestinal obstruction can effectively reduce the levels of inflammatory factors and improve the quality of life，with a significant clinical effect.