补肾活血通络汤联合依帕司他治疗糖尿病周围神经病变临床研究
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R587.2;R747.9

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Clinical Study on Bushen Huoxue Tongluo Tang Combined with Epalrestat on Diabetic Peripheral Neuropathy
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    摘要:

    目的:观察补肾活血通络汤联合依帕司他用于糖尿病周围神经病变(DPN) 的治疗效果。方法:将96 例DPN 患者随机分为西医组与中西医组各48 例。2 组予饮食调整、适当运动锻炼和控制血糖等基础治疗,西医组加服依帕司他片,中西医组在西医组基础上加服补肾活血通络汤,2 组均连续治疗12 周。比较2 组临床疗效及治疗前后中医证候积分、多伦多神经病变(TCSS) 评分及密歇根糖尿病神经病变(MDNS) 评分。结果:中西医组临床总有效率95.83%,明显优于西医组83.33%(P<0.05)。与同组治疗前比较,治疗后2 组下肢麻木、烧灼感、刺痛和感觉异常等中医证候积分及TCSS、MDNS 评分均降低(P<0.05);与西医组治疗后比较,中西医组下肢麻木、烧灼感、刺痛和感觉异常等中医证候积分及TCSS、MDNS 评分均较低(P<0.05)。结论:补肾活血通络汤联合依帕司他用于DPN 患者的疗效优于单用依帕司他治疗,更能改善临床症状,加快患者受损神经功能恢复。

    Abstract:

    Abstract: Objective: To observe the curative effect of the therapy of Bushen Huoxue Tongluo tang combined with epalrestat on diabetic peripheral neuropathy(DPN). Methods:A total of 96 patients with DPN were randomly divided into the western medicine group and the Chinese and western medicine group, with 48 cases in each group. The two groups were treated with basic treatment,such as diet adjustment, appropriate exercise, and control of blood glucose. The western medicine group was additionally treated with epalrestat tablets,and the Chinese and western medicine group was additionally treated with Bushen Huoxue Tongluo tang based on the treatment of the western medicine group. Both groups were treated for 12 weeks. The scores of Chinese medicine syndromes, Toronto Clinical Scoring System(TCSS), and Michigan Diabetic Neuropathy Score(MDNS) before and after treatment and clinical effects were compared between the two groups. Results: The total effective rate was 95.83% in the Chinese and western medicine group, significantly better than that of 83.33% in the western medicine group(P<0.05). After treatment,the Chinese medicine syndrome scores of pnumbness,burning sensation,stabbing pain,and abnormal sensation of lower limbs, and the TCSS and MDNS scores in the two groups were decreased when compared with those before treatment(P<0.05);after treatment,the above scores in the Chinese and western medicine group were lower than those in the western medicine group(P<0.05). Conclusion: The therapy of Bushen Huoxue Tongluo tang combined with epalrestat has a better curative effect on patients with DPN than the simple treatment with epalrestat,which can improve the clinical symptoms and accelerate the recovery of damaged neurological function in patients.

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朱高辉,陈正汉.补肾活血通络汤联合依帕司他治疗糖尿病周围神经病变临床研究[J].新中医,2022,54(13):65-68

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  • 在线发布日期: 2022-07-07
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