先后天方加减治疗消化性溃疡临床研究
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R573.1

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Clinical Study on Modified Xianhoutian Prescription for Peptic Ulcer
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    摘要:

    目的:观察先后天方加减治疗消化性溃疡(PU) 的临床疗效及对血清生长因子水平的影响。方法:采用随机数字表法将124 例PU 患者均分为观察组和对照组各62 例。观察组采用先后天方加减治疗,对照组给予奥美拉唑肠溶片和铝碳酸镁片口服治疗,疗程均为6 周。比较2 组治疗前后中医证候积分及血清生长因子水平,比较2 组临床疗效、复发情况及不良反应发生情况。结果:观察组总有效率95.16%,高于对照组87.10%,2 组比较,差异无统计学意义(P>0.05)。与同组治疗前比较,治疗后2 组胃脘隐痛、四肢倦怠、畏寒肢冷、口淡流涎、便溏、纳少等中医证候积分均降低(P<0.05),血清表皮生长因子(EGF)、转化生长因子-α (TGF-α)、碱性成纤维细胞生长因子(bFGF) 及血管内皮生长因子(VEGF) 水平均升高(P<0.05);与对照组治疗后比较,观察组胃脘隐痛、四肢倦怠、畏寒肢冷、口淡流涎、便溏、纳少等中医证候积分均较低(P<0.05), 血清EGF、TGF-α、bFGF、VEGF 水平均较高(P<0.05)。观察组随访1 年内复发率11.86%,低于对照组27.78%(P<0.05)。观察组不良反应发生率8.06%,低于对照组14.52%,2 组比较,差异无统计学意义(P>0.05)。结论:先后天方加减治疗PU 脾胃虚寒证可提升患者血清生长因子表达水平,从而促进胃黏膜修复和患者症状缓解,提升治疗效果并降低复发率。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of modified Xianhoutian prescription on peptic ulcer(PU) and its effect on levels of serum growth factors. Methods:A total of 124 patients with PU were divided into the observation group and the control group according to the random number table method, with 62 cases in each group. The observation group was treated with modified Xianhoutian prescription,and the control group was orally treated with omeprazole enteric-coated tablets and hydrotalcite tablets. Both groups were treated for six weeks. Before and after treatment, the Chinese medicine syndrome scores and levels of serum growth factors were compared between the two groups. The clinical effects,recurrence,and adverse reactions were compared between the two groups. Results:The total effective rate was 95.16% in the observation group,higher than that of 87.10% in the control group,there being no significance in the difference(P>0.05). After treatment,the Chinese medicine syndrome scores of dull pain in the stomach cavity,fatigue in four limbs,fear of cold and cold limbs,bland taste in the mouth and salivation, thin and unformed stool and poor appetite in the two groups were decreased when compared with those before treatment(P<0.05), and the levels of serum epidermal growth factor(EGF), transforming growth factor- α(TGF- α), basic fibroblast growth factor(bFGF), and vascular endothelial growth factor(VEGF) were increased(P<0.05); after treatment, the above Chinese medicine syndrome scores in the observation group were lower than those in the control group(P<0.05), and the levels of serum EGF, TGF- α, bFGF, and VEGF were higher(P<0.05). During one year of follow- up, the recurrence rate was 11.86% in the observation group,lower than that of 27.78% in the control group(P< 0.05). The incidence of adverse reactions was 8.06% in the observation group,lower than that of 14.52% in the control group(P>0.05). Conclusion: The therapy of modified Xianhoutian prescription for PU with deficiency- cold of the spleen and stomach syndrome can improve the levels of serum growth factors, promote the recovery of gastric mucosa,relieve the symptoms of patients,improve the curative effects, and reduce the recurrence rates.

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王琴琴.先后天方加减治疗消化性溃疡临床研究[J].新中医,2022,54(13):60-64

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  • 在线发布日期: 2022-07-07
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