补中益气汤联合西药治疗心脾两虚型抑郁症疲劳感临床研究
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R749.4

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浙江省中医药科技计划项目(2021ZB232)


Clinical Study on Buzhong Yiqi Tang Combined with Western Medicine for Fatigue in Depression of Heart-Spleen Deficiency Type
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    摘要:

    目的:观察补中益气汤联合西药治疗心脾两虚型抑郁症疲劳感的疗效。方法:选取60 例心脾两虚型抑郁症患者,按随机数字表法分为对照组及研究组各30 例。对照组给予盐酸氟西汀分散片,研究组在对照组基础上加用补中益气汤,2 组均治疗4 周。比较2 组治疗前、治疗2 周后、治疗4 周后汉密尔顿抑郁量表-17(HAMD-17)、疲劳量表-14(FS-14) 评分的变化,比较2 组治疗过程中不良反应发生情况。结果:治疗2 周、治疗4 周后,2 组HAMD-17 评分均较治疗前下降,差异均有统计学意义(P<0.05);治疗4 周后,研究组HAMD-17 评分低于对照组,差异有统计学意义(P<0.05)。治疗2 周、治疗4 周后,2 组躯体疲劳分、脑力疲劳分、疲劳总分均较治疗前下降,差异均有统计学意义(P<0.05);治疗2 周后,研究组疲劳总分低于对照组,差异有统计学意义(P<0.05);治疗4 周后,研究组躯体疲劳分、疲劳总分均低于对照组,差异有统计学意义(P<0.05)。治疗2 周、治疗4 周后,2 组躯体疲劳分、脑力疲劳分、疲劳总分均较治疗前下降,差异均有统计学意义(P<0.05);治疗2 周后,研究组疲劳总分低于对照组,差异有统计学意义(P<0.05);治疗4 周后,研究组躯体疲劳分、疲劳总分均低于对照组,差异均有统计学意义(P<0.05)。在治疗过程中,对照组不良反应发生率为13.33%;研究组不良反应发生率为6.67%,2 组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:补中益气汤联合西药治疗心脾两虚型抑郁症疲劳感患者能减少抑郁程度、缓解疲劳,能够增强西药的临床效应,且增效作用具有明显的疗程特点。

    Abstract:

    Abstract: Objective: To observe the curative effect of Buzhong Yiqi tang combined with western medicine for fatigue in depression of heart-spleen deficiency type. Methods:A total of 60 cases of patients with depression of heart- spleen deficiency type were divided into the control group and the study group according to the random number table method,with 30 cases in each group. The control group was treated with fluoxetine hydrochloride dispersible tablets, and the study group was additionally treated with Buzhong Yiqi tang based on the treatment of the control group. Both groups were treated for four weeks. Before treatment,and after two-week and four-week treatment,the changes in scores of the 17-item Hamilton Depression Rating Scale(HAM- D17) and the Fatigue Scale- 14(FS- 14) in the two groups were compared. During treatment, the incidence of adverse reactions in the two groups were compared. Results: After two- week and four- week treatment, the HAMD17 scores in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05). After fourweek treatment, the HAMD17 score in the study group was lower than that in the control group, the difference being significant(P<0.05). After two- week and four- week treatment, the scores of physical fatigue and mental fatigue and the total scores of fatigue in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05). After two-week treatment,the total score of fatigue in the study group was lower than that in the control group,the difference being significant (P<0.05). After four- week treatment, the score of physical fatigue and the total score of fatigue in the study group were lower than those in the control group, differences being significant(P<0.05). During treatment, the incidence of adverse reactions was 13.33% in the control group and 6.67% in the study group,there being no significant difference being found in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Buzhong Yiqi tang combined with western medicine for fatigue in depression of heart-spleen deficiency type can decrease depressive degree,relieve fatigue,and enhance the clinical effect of western medicine,whose synergistic effect has significant time course features.

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刘传勇,陈广烈,张丽娜,朱双阅,赵黎君,时增科.补中益气汤联合西药治疗心脾两虚型抑郁症疲劳感临床研究[J].新中医,2022,54(13):1-5

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  • 在线发布日期: 2022-07-07
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