Abstract：Objective：To observe the nutritional status of Shiquan Dabu tang combined with enteral nutrition support on patients after colorectal cancer radical surgery and its immune function. Methods：A total of 80 cases after colorectal cancer radical surgery were selected and randomly divided into the treatment group and the control group，40 cases in each group. The control group was given enteral nutrition support， and the treatment group was additionally given Shiquan Dabu tang based on the treatment of the control group. The scores of Chinese medicine syndrome scores，nutritional status，immune function and adverse reactions were compared between the two groups. Results： Before treatment， there was no significant difference in the scores of Chinese medicine syndromes such as poor food intake， abdominal distension， abdominal pain，shortness of breath，laziness to speak，mental fatigue and lack of strength between the two groups(P＜ 0.05). After treatment， the above scores of syndromes in both groups were decreased when compared with those before treatment(P＜0.05)，and the scores in treatment group were lower than those in control group(P＜0.05). Before treatment， there was no significant difference in serum albumin(ALB)，serum pre- albumin(PAB) and transferrin(TRF) between the two groups(P＞0.05). After treatment，the levels of Alb，PAB and TRF in both groups were increased when compared with those before treatment(P＜0.05)，and the above levels in the treatment group were higher than those in the control group(P＜0.05). Before treatment，there was no significant difference in Immunoglobulin-A，G，M(IgA，IgG，IgM)，T lymphocyte subsets (CD3+，CD4+)，CD4+/CD8+ between the two groups(P＞0.05). After treatment，the levels of IgA，IgG，IgM，CD3+，CD4+， CD4+/CD8+ in the two groups were increased when compared with those before treatment(P＜0.05)，and the above levels in the treatment group were higher than those in the control group(P＜0.05). The incidence of adverse reactions was 15.00% in the treatment group and 12.50% in the control group，there being significant difference between the two groups(P＞0.05). Conclusion： Shiquan Dabu tang combined with enteral nutritional support can improve the nutritional status and immune function of patients after colorectal surgery，with no significant increase in adverse reactions.