Abstract： Objective： To observe the clinical effect of Qingwei Xiehuo tang on the treatment of plaque gingivitis with syndrome of intense stomach heat. Methods： A total of 92 patients with plaque gingivitis with syndrome of intense stomach heat were selected and divided into the control group and the study group according to random number table method，with 46 cases in each group. The control group was given ultrasonic cleaning， chlorhexidine gargle and other conventional treatments， and the study group was additionally given Qingwei Xiehuo tang based on the treatment of the control group. Both groups were treated for two weeks.The clinical effects in the two groups were compared. The levels of Plaque Index (PLI)，Gingival Index(GI) and Sulcus Bleeding Index(SBI) as well as levels of tumor necrosis factor- α(TNF-α)，interleukin-6 (IL- 6) and interleukin- 8(IL- 8) in gingival crevicular fluid in both groups were compared before and after treatment. The adverse reactions were recorded. Results： The total effective rate was 97.83% in the study group， higher than that of 82.61% in the control group(P＜0.05). After treatment，the levels of PLI，GI and SBI in both groups were decreased when compared with those before treatment(P＜0.05)，and the above three levels in the study group were lower than those in the control group(P＜0.05). After treatment，the levels of TNF-α，IL-6 and IL-8 in gingival crevicular fluid in both groups were decreased when compared with those before treatment(P＜0.05)，and the above three levels in gingival crevicular fluid in the study group were lower than those in the control group(P＜0.05). During treatment，no obvious adverse reactions occurred in both groups. Conclusion：Qingwei Xiehuo tang has a significant therapeutic effect on the treatment of plaque gingivitis with syndrome of intense stomach heat， which can effectively improve the periodontal environment of patients and reduce the levels of inflammatory factors in gingival crevicular fluid with great safety.