Abstract：Objective：To observe the clinical effect of Xiao'er Feike granules combined with tuina with manipulation based on routine western medicine for children with acute bronchitis of phlegm-dampness accumulation in lung type. Methods：A total of 140 cases of children were selected as study objects，and were divided into the control group and the study group according to the random number table method，with 70 cases in each group. Both groups were treated with ambroxol oral solution，and the study group was additionally treated with the oral administration of Xiao'er Feike granules combined with tuina with manipulation. Both groups were treated for seven days. Before treatment and after seven- day treatment respectively，the levels of tumor necrosis factor-α(TNF-α)，hypersensitive C-reactive protein(hs-CRP)，interleukin-6(IL-6) and interleukin- 8(IL- 8) in serum in the two groups were detected. The clinical effects and the curatives effects of Chinese medicine syndromes in the two groups were compared. The incidences of adverse drug reactions during treatment were observed. Results：After seven days of treatment，the total effective rates of clinical effect and curative effect of Chinese medicine syndromes in the study group were higher than those in the control group，differences being significant(P＜0.05). The levels of TNF-α，hs-CRP，IL-6 and IL-8 in serum in the two groups were decreased when compared with those before treatment(P＜0.05)；the levels of TNF-α，hs-CRP，IL-6 and IL-8 in the study group were lower than those in the control group(P＜0.05). During treatment，there was no adverse reaction caused by medicines in the two groups. Conclusion：Based on routine western medicine， the additional therapy of Xiao'er Feike granules combined with tuina with manipulation can effectively reduce the degree of inflammatory responses， relieve clinical symptoms and improve the curative effect， with good safety.