Abstract：Objective：To observe the clinical effect of the therapy of Xian Yimucao capsules combined with oxytocin on postpartum lochiorrhea. Methods：A total of 92 patients with postpartum lochiorrhea were divided into the control group and the observation group according to the random number table method，with 46 cases in each group. The control group was treated with oxytocin injection，and the observation group was additionally treated with Xian Yimucao capsules based on the treatment of the control group. Both groups were continuously treated for seven days. The clinical effects， descent of uterus，sum of three uterine diameters，duration of lochia，symptom relief time and incidences of adverse reactions were compared between the two groups. Results：The clinical effect in the observation group was better than that in the control group(P＜0.05). After treatment，the descent of uterus in the two groups were increased when compared with those before treatment(P＜0.05)，and the sum of three uterine diameters were reduced(P＜0.05)；the descent of uterus in the observation group was greater than that in the control group(P＜0.05)，and the sum of three uterine diameters was less than that in the control group(P＜0.05). The duration of lochia and relief time of abdominal pain，uterine tenderness and bearing- down and distending pain of low back and abdomen in the observation group were shorter than those in the control group(P＜0.05). The incidence of adverse reactions was 8.70% in observation group， and was 4.35% in the control group， there being no significance in the difference(P＞0.05). Conclusion：The therapy of Xian Yimucao capsules combined with oxytocin has a good curative effect on postpartum lochiorrhea，which can relieve the clinical symptoms and shorten the course of disease，with good safety.