柴胡消渴汤联合甘精胰岛素治疗糖尿病胰岛素抵抗临床研究
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Clinical Study of Chaihu Xiaoke Tang Combined with Insulin Glargine for Diabetic Insulin Resistance
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    摘要:

    目的:观察柴胡消渴汤联合甘精胰岛素治疗糖尿病胰岛素抵抗的临床疗效。方法:选取69 例糖尿病胰岛素抵抗患者,按随机数字表法分成对照组34 例及试验组35 例。对照组给予甘精胰岛素治疗,试验组给予甘精胰岛素联合柴胡消渴汤治疗,2 组均治疗3 个月。比较2 组治疗前后空腹血糖、餐后2 h 血糖,以及稳态模型胰岛素抵抗指数(HOMA-IR)、稳态模型胰岛β 细胞功能指数(HOMA-β)、空腹胰岛素(FINS) 和胰岛素敏感指数(ISI);比较2 组临床疗效及不良反应发生率。结果:治疗后,2 组空腹血糖、餐后2 h 血糖均较治疗前降低(P<0.05),试验组空腹血糖、餐后2 h 血糖均低于对照组(P<0.05)。治疗后,2 组HOMA-IR、FINS 均较治疗前降低(P<0.05),HOMA-β、ISI 均较治疗前升高(P<0.05);试验组HOMA-IR、FINS 均低于对照组(P<0.05),HOMA-β、ISI 均高于对照组(P<0.05)。试验组总有效率94.29%,高于对照组76.47% (P<0.05)。试验组不良反应发生率11.43%,与对照组8.82%比较,差异无统计学意义(P>0.05)。结论:柴胡消渴汤联合甘精胰岛素治疗糖尿病胰岛素抵抗,可降低患者的血糖水平,改善胰岛素抵抗,且安全性好。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of Chaihu Xiaoke tang combined with insulin glargine for diabetic insulin resistance. Methods:A total of 69 patients with diabetic insulin resistance were selected and divided into the control group and the experiment group according to the random number table method,with 34 and 35 cases in each group respectively. The control group was treated with insulin glargine,and the experiment group was treated with insulin glargine combined with Chaihu Xiaoke tang. Both groups were treated for three months. Before and after treatment, the fasting blood glucose, postprandial 2-hour blood glucose,Insulin glargine,Homeostasis Model Assessment of Insulin Resistance (HOMA- IR), Homeostasis Model Assessment of Islet Beta Cell Function(HOMA- β), fasting insulin(FINS) and insulin sensitivity index(ISI) were compared between the two groups. The clinical effects and incidence of adverse reactions were compared between the two groups. Results: After treatment, the fasting blood glucose and postprandial 2- hour blood glucose in the two groups were decreased when compared with those before treatment(P<0.05), and the above two indexes in the experiment group were lower than those in the control group(P<0.05). After treatment,the HOMA- IR and FINS in both groups were decreased when compared with those before treatment(P<0.05),and the HOMA-β and ISI were increased(P<0.05);the HOMA-IR and FINS in the experiment group were lower than those in the control group(P<0.05), and the HOMA- β and ISI were higher(P<0.05). The total effective rate was 94.29% in the experiment group,higher than that of 76.47% in the control group(P<0.05). The incidence of adverse reactions was 11.43% in the experiment group,and was 8.82% in the control group,there being no significance in the difference(P>0.05). Conclusion:The therapy of Chaihu Xiaoke tang combined with insulin glargine for diabetic insulin resistance can reduce the level of blood glucose in patients and improve the insulin resistance,with good safety.

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黄佩芬.柴胡消渴汤联合甘精胰岛素治疗糖尿病胰岛素抵抗临床研究[J].新中医,2022,54(12):97-100

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  • 在线发布日期: 2022-06-22
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