Abstract：Objective：To observe the clinical effect of the therapy of Chaihu Xiaoke tang combined with insulin glargine for diabetic insulin resistance. Methods：A total of 69 patients with diabetic insulin resistance were selected and divided into the control group and the experiment group according to the random number table method，with 34 and 35 cases in each group respectively. The control group was treated with insulin glargine，and the experiment group was treated with insulin glargine combined with Chaihu Xiaoke tang. Both groups were treated for three months. Before and after treatment， the fasting blood glucose， postprandial 2-hour blood glucose，Insulin glargine，Homeostasis Model Assessment of Insulin Resistance (HOMA- IR)， Homeostasis Model Assessment of Islet Beta Cell Function(HOMA- β)， fasting insulin(FINS) and insulin sensitivity index(ISI) were compared between the two groups. The clinical effects and incidence of adverse reactions were compared between the two groups. Results： After treatment， the fasting blood glucose and postprandial 2- hour blood glucose in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above two indexes in the experiment group were lower than those in the control group(P＜0.05). After treatment，the HOMA- IR and FINS in both groups were decreased when compared with those before treatment(P＜0.05)，and the HOMA-β and ISI were increased(P＜0.05)；the HOMA-IR and FINS in the experiment group were lower than those in the control group(P＜0.05)， and the HOMA- β and ISI were higher(P＜0.05). The total effective rate was 94.29% in the experiment group，higher than that of 76.47% in the control group(P＜0.05). The incidence of adverse reactions was 11.43% in the experiment group，and was 8.82% in the control group，there being no significance in the difference(P＞0.05). Conclusion：The therapy of Chaihu Xiaoke tang combined with insulin glargine for diabetic insulin resistance can reduce the level of blood glucose in patients and improve the insulin resistance，with good safety.