银杏达莫联合前列地尔治疗急性脑梗死临床研究
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R743.3

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Clinical Study on Ginkgo Damol Combined with Alprostadil for Acute Ischemic Stroke
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    摘要:

    目的:观察银杏达莫联合前列地尔治疗急性脑梗死(AIS) 的临床疗效。方法:选取80 例AIS 患者,采用随机数字表法分为对照组和试验组,每组40 例。对照组给予注射用前列地尔治疗,试验组在对照组基础上加用银杏达莫注射液治疗,2 组均治疗14 d。比较2 组血液流变学指标[全血高切黏度、全血低切黏度、血浆黏度(PV)、红细胞比容(HCT)、红细胞沉降率(ESR) 及D-二聚体(D-D)]、血小板活性标志物(PAC-1、CD62P、CD63)、炎症因子[肿瘤坏死因子(TNF) -α、白细胞介素(IL) -6、超敏C-反应蛋白(hs-CRP)]水平及美国国立卫生研究院卒中量表(NIHSS) 评分。结果:治疗后,2 组全血高切黏度、全血低切黏度、PV、HCT、ESR、D-D、PAC-1、CD62P、CD63、TNF-α、IL-6、hs-CRP 水平均较治疗前降低(P<0.05),试验组全血高切黏度、全血低切黏度、PV、HCT、ESR、D-D、PAC-1、CD62P、CD63、TNF-α、IL-6、hs-CRP 水平均低于对照组(P<0.05)。治疗后,2 组NIHSS 评分均较治疗前降低(P<0.05),试验组NIHSS 评分低于对照组(P<0.05)。结论:银杏达莫联合前列地尔治疗AIS,可有效改善患者的血液流变学与血小板活性,抑制机体炎症反应,促进神经功能恢复。

    Abstract:

    Abstract: Objective: To observe the clinical effect of the therapy of ginkgo damol combined with alprostadil on acute ischemic stroke(AIS). Methods:A total of 80 AIS patients were selected and divided into the control group and the experiment group by random number table method,with 40 cases in each group. The control group was injected with alprostadil,and the experiment group was additionally injected with ginkgo damol based on the treatment of the control group. Both groups were treated for 14 days. The levels of hemorheological indexes including whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity(PV),hematocrit(HCT),erythrocyte sedimentation rate(ESR) and D-dimer(D-D),platelet activity markers including PAC- 1, CD62P and CD63, inflammatory factors including tumor necrosis factor- α(TNF- α), interleukin(IL)- 6 and hypersensitive C- reactive protein(hs- CRP),and the National Institutes of Health Stroke Scale(NIHSS) scores were compared between the two groups. Results:After treatment,the levels of whole blood high shear viscosity, whole blood low shear viscosity, PV, HCT, ESR, D- D, PAC- 1, CD62P, CD63, TNF- α, IL- 6 and hs- CRP in both groups were decreased when compared with those before treatment(P<0.05),and the above levels in the experiment group were lower than those in the control group(P<0.05). After treatment, the NIHSS scores in both groups were lower than those before treatment(P<0.05),and the NIHSS score in the experiment group was lower than that in the control group(P< 0.05). Conclusion: The therapy of ginkgo damol combined with alprostadil can effectively improve the hemorheology and platelet activity of patients with AIS,inhibit the body's inflammatory responses,and promote the recovery of nerve function.

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陈玲,黄林凤,杨林慧.银杏达莫联合前列地尔治疗急性脑梗死临床研究[J].新中医,2022,54(12):90-93

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  • 在线发布日期: 2022-06-22
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