Abstract： Objective： To observe the effects of Yiqi Jianpi Lishui prescription on chronic heart failure(CHF) and brain natriuretic peptide(BNP) level in plasma. Methods： A total of 76 cases of CHF patients were included and divided into the observation group and the control group according to the random number table method，with 38 cases in each group. Both groups were given basic treatment；the control group was given β blockers and other routine western medicine treatments to dilate blood vessels and strengthen heart and promote diuresis； the observation group was additionally treated with Yiqi Jianpi Lishui prescription based on the treatment of the control group. Clinical effects，levels of BNP in plasma，6- minute walking distance and the improvement in heart function[stroke volume(SV)、left ventricular ejection fractions(LVEF)] were observed in the two groups. Results：The total effective rate in clinic was 89.47% in the observation group，higher than that of 68.42% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of BNP levels in plasma and 6-minute walking distance between the two groups(P＞ 0.05). After treatment， BNP levels in plasma in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and 6- minute walking distances were significantly increased(P＜0.05)； BNP level in the observation group was lower than that in the control group(P＜0.05)，and 6- minute walking distance was higher(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of SV and LVEF between the two groups(P＞0.05). After treatment，levels of SV and LVEF in the two groups were significantly increased when compared with those before treatment(P＜0.05)，and the two indexes in the observation group were higher than those in the control group(P＜0.05). Conclusion：Yiqi Jianpi Lishui prescription has a significant curative effect in the treatment of CHF and can improve heart function，BNP and prolong 6-minute walking distance.