基于现代文献的老年轻度认知功能障碍中医治疗现状及证型证素研究
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R277.7

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浙江省中医药科技计划科研基金项目(2015ZA017)


Study on Chinese Medicine Treatment Status, Syndrome Types and Syndrome Elements of Senile Mild Cognitive Impairment Based on Modern Literature
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    摘要:

    目的:采用文献计量学方法对中医药治疗老年轻度认知功能障碍(MCI) 的文献进行研究,并对老年MCI 的中医治疗现状和证候要素进行梳理。方法:确定检索策略,在CNKI、CBM、VIP、WanFang、PubMed、EMBASE、The Cochrane Library等数据库中检索中医药治疗老年MCI 的相关文献,根据纳入、排除标准进行文献筛选,运用SPSS17.0 软件对研究类型、研究内容、中医证素等数据进行统计分析。结果:纳入文献216 篇,按研究类型分为:随机对照试验(RCT) 研究94 篇,非RCT 研究45 篇,传统综述27 篇,横断面研究23 篇,专家经验22 篇,系统评价5 篇。89 篇中药相关文献中,出现中药复方、中成药、提取物等共72 种。69 篇记载了具体中药组成的文献中,分析得出中药130 种。74 篇文献描述了MCI 证型,归纳证候48 个,出现频率>10%的证型仅12 个,出现次数≤3 次的证型24 个,14 个证型只出现1 次;出现证素23 个,其中病位类证素10 个,病性类证素13 个。结论:缺乏中医药治疗MCI 的统一标准在一定程度上限制了本病临床论治水平的提高和系统化治疗的推广,因此需了解当前中医临床对MCI 辨证分型与治疗用药的研究现状。下一步可根据文献研究基础,制作出针对MCI 的中医调查问卷,优化该病证候学研究的方法,为中医药治疗MCI 诊疗方案的制定提供依据,促进中医药的临床应用,提高疗效。

    Abstract:

    Abstract:Objective:To study the literature on Chinese medicine treatment of senile mild cognitive impairment(MCI) by bibliometric method,and to sort out the status quo and syndrome elements of Chinese medicine treatment of senile MCI. Methods:The retrieval strategy was determined;the relevant literature on Chinese medicine treatment of senile MCI was retrieved from CNKI, CBM, VIP, WanFang, PubMed, EMBASE, The Cochrane Library and other databases, and the literature was screened according to inclusion and exclusion criteria;SPSS17.0 software was used for statistical analysis of the data including research types , research contents and Chinese medicine syndrome elements. Results : A total of 216 pieces of literature were included and divided into 94 randomized controlled trial(RCT) studies, 45 non-RCT studies, 27 traditional reviews, 23 cross- sectional studies, 22 expert experiences and 5 systematic reviews according to their research types. Among the 89 pieces of literature related to Chinese medicine,there appeared 72 kinds of Chinese herbal compound, Chinese patent medicine and extract. Among the 69 documents that recorded the specific composition of Chinese medicines, 130 kinds of Chinese medicines were obtained through analysis. A total of 74 pieces of literature described the syndrome types of MCI,with 48 syndromes being summarized;there were only 12 syndrome types with a frequency of over 10%,24 syndrome types with a frequency of less than or equal to 3 times,and 14 syndrome types only appeared for once;there were 23 syndrome elements,including 10 disease-location syndrome elements and 13 diseasetype syndrome elements. Conclusion:At present,there is still a lack of unified standard for the treatment of MCI by Chinese medicine,which restricts the improvement of clinical treatment level and the promotion of systematic treatment of MCI to a certain extent. Therefore,it is necessary to understand the current research status of syndrome differentiation,treatment and medication of MCI by Chinese medicine. In the next step,according to the basis of literature research,the questionnaire of Chinese medicine for MCI can be developed to optimize the method of syndrome research of MCI,provide a basis for the formulation of diagnosis and treatment plan of Chinese medicine for MCI, promote the clinical application of Chinese medicine and improve the curative effect.

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王翰,姚铁飞,韩梅,谢征雯.基于现代文献的老年轻度认知功能障碍中医治疗现状及证型证素研究[J].新中医,2022,54(12):34-38

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  • 在线发布日期: 2022-06-22
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