Abstract： Objective： To explore the mechanism of Erchen tang for chronic obstructive pulmonary disease(COPD） based on network pharmacology. Methods： Through the establishment of Erchen tang target dataset and COPD target dataset， the “component- target- disease” interaction network of Erchen tang for COPD was constructed， and visual analysis was performed to predict the mechanism of Erchen tang for COPD. Results： Based on the construction of the “component- target- disease” interactive network， it was found that the main active ingredients of Erchen tang were baicalein， stigmasterol， beta- sitosterol， quercetin， isorhamnetin and vicenin- 2， which could act directly on cyclin E1 (CCNE1)， cyclin dependent kinase 1(CDK1)， cyclin dependent kinase 2(CDK2)， cyclin dependent kinase inhibitor 1A (CDKN1A)， transforming growth factor beta 1(TGFβ1)， tumor protein p53(TP53)， proliferating cell nuclear antigen(PCNA)， inhibitor of kappa polypeptide gene enhancer in B- cells， kinase beta(IKBKβ)， transforming growth factor beta receptor 1 (TGFβR1) and heat shock protein 90 alpha family class A member 1(HSP90αA1) to play a therapeutic role. A total of 16 related biological pathways were screened out through enrichment analysis of KEGG pathway. A total of 30 related biological pathways were screened out through enrichment analysis of GO pathway. Conclusion：Mainly through the targets including CCNE1，CDK1，CDK2，CDKN1A，TGFβ1，TGFβR1，PCNA，TP53，IKBKβ and HSP90αA1，Erchen tang intervenes in the COPD- induced inflammatory response， cell senescence， tissue remodeling and other mechanisms so as to achieve the purpose of controlling the occurrence and development of COPD.