仙灵骨葆胶囊联合唑来膦酸盐、钙尔奇D 治疗骨质疏松症疗效观察及对骨代谢指标的影响
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Curative Effect of Xianling Gubao Capsules Combined with Zoledronic Acid and Calcir D on Osteoporosis and Its Effect on Bone Metabolism Indexes
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    摘要:

    目的:观察仙灵骨葆胶囊联合唑来膦酸盐、钙尔奇D 治疗骨质疏松症(OP) 的疗效及对骨代谢指标的影响。方法:选取90 例OP 患者,按数字奇偶法分为治疗组及对照组各45 例,对照组给予唑来膦酸盐联合钙尔奇D 治疗,治疗组在对照组基础上给予仙灵骨葆胶囊治疗,2 组均以4 周为1 个疗程,连续治疗6 个疗程。比较2 组临床疗效,比较2 组治疗前后中医证候积分、数字疼痛评分法(NRS) 评分、骨痛、骨密度、骨代谢[血磷(P)、血钙(Ca)、碱性磷酸酶(ALP)]的变化。结果:治疗组临床疗效总有效率为95.56%,对照组为80.00%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组中医证候积分、NRS评分较治疗前下降,治疗组中医证候积分、NRS 评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组腰椎L1~4、股骨颈骨密度水平均较治疗前上升,治疗组腰椎L1~4、股骨颈骨密度水平均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组P、Ca、ALP 水平较治疗前上升,治疗组P、Ca、ALP 水平均高于对照组,差异均有统计学意义(P<0.05)。结论:仙灵骨葆胶囊联合唑来膦酸盐、钙尔奇D 治疗OP 疗效显著,可有效缓解临床症状,减轻骨痛程度,增加骨密度,改善骨代谢水平。

    Abstract:

    Abstract:Objective:To observe the curative effect of the therapy of Xianling Gubao capsules combined with zoledronic acid and calcir D on osteoporosis and its effect on bone metabolism indexes. Methods: A total of 90 OP patients were selected and divided into the treatment group and the control group by numerical odd-even method,with 45 cases in each group. The control group was given zoledronate acid and calcir D, and the treatment group was additionally given Xianling Gubao capsules based on the treatment of the control group. Both groups were treated for six courses of treatment, four weeks being one course. The clinical effects in the two groups were observed, and the changes of Chinese medicine syndrome scores,scores of Numerical Rating Scale(NRS),bone pain,bone mineral density and bone metabolism indexes, including blood phosphorus(P), blood calcium(Ca), alkaline phosphatase(ALP), were compared between the two groups before and after treatment. Results:The total clinical effective rate was 95.56% in the treatment group and 80.00% in the control group,the difference being significant(P<0.05). After treatment,the Chinese medicine syndrome scores and NRS scores in the two groups were decreased when compared with those before treatment,and the Chinese medicine syndrome score and NRS score in the treatment group were lower than those in the control group, differences being significant(P< 0.05). After treatment, the bone mineral density of lumbar L1- 4 and femoral neck in both groups was increased when respectively compared with that before treatment,and the bone mineral density of lumbar L1-4 and femoral neck in treatment group was respectively higher than that in the control group, differences being significant(P<0.05). After treatment, the levels of P,Ca and ALP in both groups were increased when compared with those before treatment,and the above three levels in the treatment group were higher than those in the control group,differences being significant(P<0.05). Conclusion: The therapy of Xianling Gubao capsules combined with zoledronic acid and calcir D has a significant curative effect on the treatment of OP, which can effectively relieve the clinical symptoms, reduce the degree of bone pain, increase bone mineral density and improve bone metabolism.

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潘方瑛,张健儿,郑美暄.仙灵骨葆胶囊联合唑来膦酸盐、钙尔奇D 治疗骨质疏松症疗效观察及对骨代谢指标的影响[J].新中医,2022,54(11):138-141

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  • 在线发布日期: 2022-06-10
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