Abstract： Objective： To observe the curative effect of Liniao Paishi tang combined with tamsulosin hydrochloride sustained release capsules on patients after holmium laser lithotripsy for ureteral calculi. Methods： A total of 110 cases of patients who had ureteral calculi and underwent holmium laser lithotripsy were selected and divided into the control group and the treatment group according to the random number table method，with 55 cases in each group. Both groups were treated with holmium laser lithotripsy under ureteroscope； the control group was given the postoperative oral administration with tamsulosin hydrochloride sustained release capsules，and the treatment group was additionally treated with Liniao Paishi tang based on the treatment of the control group. Both groups were treated for two weeks. The changes in indexes of renal tubular function impairment including urinary N- acetyl- β- D- glucosaminidase(NAG) and β2- microglobulin(β2- MG) before and after treatment，clinical effects，and the stone clearance rate and the incidence of complications after two-week treatment were compared between the two groups. Results： After two- week treatment， the total effective rate of clinical effect was 96.36% in the treatment group and 85.45% in the control group，the difference being significant(P＜0.05). After two-week treatment， levels of urinary NAG and β2- MG in the two groups were decreased when compared with those before treatment，and the two levels in the treatment group were lower than those in the control group，differences being significant (P＜0.05). According to the reexamination after two- week treatment，the ureteral stone clearance rate was 94.55% in the treatment group， higher than that of 81.82% in the control group， differences being significant(P＜0.05). As for the complications，the incidence of renal colic was 9.09% in the treatment group and 23.64% in the control group，the difference being significant(P＜0.05)； there was no significant difference being found in the comparison of incidences of urinary tract infection，nausea and vomiting between the two groups(P＞0.05). Conclusion：Liniao Paishi tang combined with tamsulosin hydrochloride sustained release capsules has a defined curative effect in the treatment of patients after holmium laser lithotripsy for ureteral calculi，and can reduce the damage of renal function and the occurrence of renal colic，and accelerate the discharge of stone.