Abstract：Objective：To observe the clinical effect of syndrome differentiation and treatment of diabetic gastroparesis. Methods：A total of 60 cases of patients with diabetic gastroparesis were selected and divided into the observation group and the control group according to different treatment methods，with 30 cases in each group. The control group was treated with domperidone tablets，and the observation group was additionally treated with Chinese medicine syndrome differentiation and treatment based on the treatment of the control group. Before and after treatment， dynamic changes of blood glucose， times of hypoglycemia，symptom scores，gastric emptying time，gastric function and symptom disappearance time were compared between the two groups. Clinical effects were evaluated. Results： The total effective rate was 93.3% in the observation group， higher than that of 73.3% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of mean amplitude of glycemic excursion (MAGE)， mean blood glucose value(MBG)， hypoglycemia times and symptom scores between the two groups(P＞0.05). After treatment， MAGE， MBG， hypoglycemia times and symptom scores in the two groups were decreased when compared with those before treatment，and the four indexes in the observation group were lower than those in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of gastric emptying time and levels of motilin， gastrin， and ghrelin between the two groups(P＞0.05). After treatment，gastric emptying time and levels of motilin，and gastrin in the two groups were decreased when compared with those before treatment，and the three indexes in the observation group were lower than those in the control group(P＜0.05)； ghrelin levels in the two groups were increased when compared with those before treatment，and the level in the observation group was lower than that in the control group(P＜0.05). Conclusion： Chinese medicine syndrome differentiation and treatment has a good clinical effect in the treatment of diabetic gastroparesis， and can regulate blood glucose level and improve clinical symptoms and gastric function.