Abstract： Objective： To observe the clinical effect of Fuzheng Kanglao prescription combined with quadruple chemotherapy for pulmonary tuberculosis of deficiency of both qi and yin type. Methods：A total of 112 cases of patients with pulmonary tuberculosis of deficiency of both qi and yin type were selected as the study subjects and divided into the control group and the observation group according to the random number table method， with 50 and 62 cases in each group respectively. The control group was treated with routine quadruple chemotherapy for anti- tuberculosis treatment， and the observation group was additionally given oral administration of Fuzheng Kanglao prescription based on the treatment of the control group. Both groups were treated for four weeks. The changes in Chinese medicine syndrome scores，inflammatory factors in serum including interleukin- 6(IL- 6)， interleukin- 10(IL- 10) and tumor necrosis factor- α(TNF- α)， and T cell subsets indexes before and after treatment，and the clinical effects in the two groups were compared. Results：The total effective rate of clinical effect was 90.32% in the observation group and 76.00% in the control group，the difference being significant(P＜0.05). After treatment，the scores of main symptoms and secondary symptoms and the total scores in Chinese medicine syndromes in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores of main symptoms and secondary symptoms and the total score in Chinese medicine syndromes in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the levels of IL-6 and TNF-α in serum in the two groups were decreased when compared with those before treatment，and the IL-10 levels were increased， differences being significant(P＜0.05). After treatment， the levels of IL- 6 and TNF- α in serum in the observation group were lower than those in the control group，and the IL-10 level was higher，differences being significant (P＜0.05). After treatment，the levels of CD8+ in the two groups were decreased compared with those before treatment,and the levels of CD4 + and CD4 +/CD8 + were increased compared with those before treatment,differences being significant (P＜ 0.05).The level of CD8+ in the observation group was lower than that in the control group, and the levels of CD4+ and CD4+/ CD8+ in the observation group were higher than those in the control group,differences being significant(P＜0.05). Conclusion： Fuzheng Kanglao prescription combined with quadruple chemotherapy for pulmonary tuberculosis of deficiency of both qi and yin type can effectively relieve clinical symptoms and inflammatory responses，and improve the curative effect.