Clinical Study on Wenyang Buxin Tang Combined with Western Medicine for Chronic Heart Insufficiency of Heart-Kidney Yang Deficiency Type
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摘要:
目的:观察温阳补心汤联合西药治疗心肾阳虚型慢性心功能不全的临床疗效及对患者运动耐力和心功能的影响。方法:选取100 例心肾阳虚型慢性心功能不全患者,按随机数字表法分为对照组和观察组各50 例。对照组予以常规西药治疗,观察组在对照组基础上联用温阳补心汤治疗。比较2 组临床疗效及治疗前后中医证候积分、6 min 步行距离、运动耐力指标、心功能指标。结果:治疗后,观察组总有效率88.00%,高于对照组66.00%(P<0.05)。与同组治疗前比较,2 组治疗后中医证候积分、二氧化碳通气当量斜率(VE/VCO2 slop)、左心房内径(LAD)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、N 末端B 型利钠肽原(NT-proBNP) 水平均降低(P<0.05),6 min 步行距离、峰值氧耗量(peak VO2)、无氧阈氧耗量(VO2 AT)、最大运动功率、最大运动时间、心脏指数(CI)、左室射血分数(LVEF) 水平增加(P<0.05);与对照组治疗后比较,观察组治疗后中医证候积分、6 min 步行距离、运动耐力指标、心功能指标改善更明显(P<0.05)。结论:温阳补心汤联合西药治疗心肾阳虚型慢性心功能不全疗效确切,可有效改善患者心功能和运动耐力。
Abstract:
Abstract:Objective:To observe the clinical effect of Wenyang Buxin tang combined with western medicine for chronic heart insufficiency of heart-kidney yang deficiency type and its effects on exercise endurance and heart function. Methods:A total of 100 cases of patients with chronic heart insufficiency of heart-kidney yang deficiency type were selected and divided into the control group and the observation group according to the random number table method,with 50 cases in each group. The control group was treated with routine western medicine, and the observation group was additionally treated with Wenyang Buxin tang based on the treatment of the control group. Chinese medicine syndrome scores, 6- min walking distance,exercise endurance indexes and heart function indexes before and after treatment as well as clinical effects were compared between the two groups. Results:After treatment,the total effective rate was 88.00% in the observation group, higher than that of 66.00% in the control group(P<0.05). Compared with those in the same group before treatment, the levels of Chinese medicine syndrome scores,carbon dioxide ventilation equivalent slope(VE/VCO2 slope),left atrial diameter (LAD),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD) and N-terminal B-type natriuretic peptide(NT-proBNP) in the two groups decreased(P<0.05). The 6-min walking distance,peak oxygen consumption (peak VO2), oxygen consumption at anaerobic threshold(VO2 AT), maximum exercise power, maximum exercise time, cardiac index(CI) and left ventricular ejection fraction(LVEF) were increased(P<0.05). After treatment, Chinese medicine syndrome scores,6-min walking distance,exercise endurance indexes and heart function indexes in the observation group were improved more significantly than those in the control group(P<0.05). Conclusion:Wenyang Buxin tang combined with western medicine has a defined curative effect in the treatment of chronic heart insufficiency of heart-kidney yang deficiency type and can effectively improve exercise endurance and heart function.