乌蛇荣皮汤治疗维持性血液透析皮肤瘙痒患者临床观察及对炎症因子的影响
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R692.5;R758.3+2

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Clinical Observation of Wushe Rongpi Tang Treating Pruritus in Patients Undergoing Maintenance Hemodialysis and Its Effect on Inflammatory Factors
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    摘要:

    目的:观察乌蛇荣皮汤治疗维持性血液透析皮肤瘙痒患者的临床疗效及其对血清炎症因子的影响。方法:选取慢性肾功能衰竭行维持性血液透析伴有皮肤瘙痒的患者98 例,随机分为对照组和观察组各49 例。对照组给予口服加巴喷丁、外用丁酸氢化可的松乳膏等常规治疗,观察组在对照组的基础上给予乌蛇荣皮汤治疗。2 组均以2 周为1 个疗程,共治疗3 个疗程。比较2 组临床疗效、中医证候积分、皮肤瘙痒评分、血清炎症因子[超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平及不良反应情况。结果:观察组总有效率为85.71%,对照组为67.35%,2 组比较,差异有统计学意义(P<0.05)。治疗前,2 组中医证候积分比较,差异无统计学意义(P>0.05)。治疗2、4、6 周,2 组中医证候积分均较治疗前降低(P<0.05),并呈下降趋势,且观察组各时间点的中医证候积分均低于对照组同期水平(P<0.05)。治疗前,2 组皮肤瘙痒评分比较,差异无统计学意义(P>0.05)。治疗2、4、6 周,2 组皮肤瘙痒评分均较治疗前降低(P<0.05),并呈下降趋势,且观察组各时间点的皮肤瘙痒评分均低于对照组同期水平(P<0.05)。治疗后,2 组hs-CRP、IL-6、TNF-α水平均较治疗前明显降低(P<0.05),且观察组hs-CRP、IL-6、TNF-α水平均明显低于对照组(P<0.05)。观察组不良反应发生率为8.16%,对照组为2.04%,2 组比较,差异无统计学意义(P>0.05)。结论:乌蛇荣皮汤治疗慢性肾衰竭维持性血液透析伴皮肤瘙痒患者疗效显著,可有效缓解患者临床症状,改善机体炎症因子水平,且安全性良好。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Wushe Rongpi tang treating pruritus in patients undergoing maintenance hemodialysis and its effect on inflammatory factors in serum. Methods:A total of 98 cases of patients who had chronic renal failure and were undergoing maintenance hemodialysis and complicated with pruritus were selected and randomly divided into the control group and the observation group, with 49 cases in each group. The control group was treated with the oral administration with Gabapentin, the external application with hydrocortisone cream and other routine symptomatic treatments,and the observation group was additionally treated with Wushe Rongpi tang based on the treatment of the control group. Both groups were treated for three treatment courses, with two weeks being one course. Clinical effects, Chinese medicine syndrome scores, skin pruritus scores, levels of serum inflammatory factors [high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)] and incidence of adverse reactions were compared between the two groups. Results:The total effective rate was 85.71% in the observation group,and 67.35% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05). After treatment for two, four, and six weeks, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05), and showed a downward trend, and Chinese medicine syndrome scores in the observation group at each time point were lower than those in the control group in the same period(P<0.05). Before treatment,there was no significant difference being found in the comparison of pruritus scores between the two groups(P>0.05). After treatment for two, four, and six weeks, pruritus scores in the two groups were decreased when compared with those before treatment(P<0.05),and showed a downward trend,and pruritus scores in the observation group at each time point were lower than those in the control group in the same period(P<0.05). After treatment,levels of hs-CRP,IL-6 and TNF-α in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the three levels in the observation group were significantly lower than those in the control group(P<0.05). The incidence of adverse reactions was 8.16% in the observation group and 2.04% in the control group,there being no significance being found in the difference(P< 0.05). Conclusion:Wushe Rongpi tang has a significant curative effect in the treatment of pruritus in patients who had chronic renal failure and were undergoing maintenance hemodialysis. It can effectively relieve clinical symptoms,and improve levels of body inflammatory factors with good safety.

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王玲霞.乌蛇荣皮汤治疗维持性血液透析皮肤瘙痒患者临床观察及对炎症因子的影响[J].新中医,2022,54(10):142-146

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  • 在线发布日期: 2022-05-24
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