Abstract：Objective：To observe the clinical effect of Xiao'er Xiaoshi granules combined with tuina with manipulation for children with functional dyspepsia of spleen stomach weakness type. Methods： A total of 160 cases of children with functional dyspepsia of spleen stomach weakness type were divided into the control group and the study group according to the random number table method，with 80 cases in each group. The control group was treated with the oral administration with bifidobacterium quadruple viable tablets，and the study group was additionally treated with tuina with manipulation based on the treatment of the control group. Both groups were continuously treated for 21 days. After 21- day treatment，clinical effects in the two groups were evaluated. Before and after 21-day treatment，the levels of serum pepsinogenⅠ，pepsinogen Ⅱand gastrin in the two groups were measured， and the three gastric motility indexes of gastric emptying time， gastric antrum contraction frequency and gastric antrum contraction amplitude were measured. The incidence of adverse reactions during treatment was observed and counted. Results： After treatment， the total effective rate was 96.25% in the study group，higher than that of 85.00% in the control group，the difference being significant(P＜0.05). When compared with those before treatment， gastric emptying time in the two groups were shortened， gastric antrum contraction frequency higher， and gastric antrum contraction amplitude larger， differences being significant(P＜0.01). After treatment， gastric emptying time in the study group was shorter than that in the control group，gastric antrum contraction frequency higher，and gastric antrum contraction amplitude larger，differences being significant(P＜0.01). Levels of serum pepsinogen Ⅰ，pepsinogenⅡ and gastrin in the two groups were increased when compared with those before treatment(P＜0.01)； levels of serum pepsinogenⅠ，pepsinogenⅡand gastrin in the study group were higher than those in the control group，differences being significant(P＜0.01). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P＞0.05). Conclusion： In the treatment of children with functional dyspepsia of spleen stomach weakness type， Xiao'er Xiaoshi granules combined with tuina with manipulation can effectively enhance gastrointestinal peristalsis function，regulate the secretion of pepsinogen and gastrin，and improve clinical effects，with high safety.