Abstract:Objective:To observe the clinical effect of Jianpi Yishen Xiezhuo Huoxue prescription on urinary microalbumin/ urinary creatinine, serum creatinine(SCr) and serum cystatin C(Cys- C) in patients with diabetic nephropathy in stage Ⅳ. Methods:A total of 80 cases of patients with type 2 diabetic nephropathy in stageⅣ were randomly divided into the treatment group and the control group,with 40 cases in each group. The control group was treated with basic western medicine,and the treatment group was additionally treated with Jianpi Yishen Xiezhuo Huoxue prescription based on the treatment plan of the control group. Both groups were treated for three months. The changes of Chinese medicine syndrome scores,urinary microalbumin/urinary creatinine,blood albumin,SCr and Cys-C before and after treatment in the two groups were observed. Results:After treatment,the urinary microalbumin/urinary creatinine in the treatment group was significantly lower than that before treatment,the difference being significant(P<0.01),and the urinary microalbumin/urinary creatinine in the treatment group was significantly lower than that in the control group,the difference being significant(P<0.01). After treatment,there was no significant difference being found in the comparison of blood albumin between the two groups, and there was no significant difference being found in the comparison of blood albumin before and after treatment(P>0.05). After treatment, SCr and Cys-C of patients aged from 40 to 49 and from 50 to 59 in the treatment group were decreased,and the differences before and after treatment were significant(P<0.05, P<0.01). There was no significant difference being found in the comparison of SCr and Cys- C before and after treatment in patients aged from 60 to 70 in the treatment group(P>0.05). There was no significant difference being found in the comparison of SCr and Cys- C before and after treatment in patients aged from 40 to 49, from 50 to 59 and from 60 to 70 in the control group(P>0.05). After treatment, SCr and Cys- C in patients aged from 40 to 49 and from 50 to 59 in the treatment group were compared with those in the control group respectively, differences being significant(P<0.05, P<0.01); there was no significant difference being found in the comparison of SCr and Cys-C in patients aged from 60-70 between the treatment group and the control group(P>0.05). After treatment, the total effective rate of Chinese medicine syndromes was 92.5% in the treatment group and 62.5% in the control group,the difference being significant(P<0.01). The total effective rate was 90.0% in the treatment group and 65.0% in the control group,the difference being significant(P<0.01). Conclusion:Based on the basic treatment regimen of western medicine, the additional application of Jianpi Yishen Xiezhuo Huoxue prescription can significantly improve the clinical symptoms of diabetic nephropathy in stage IV,reduce proteinuria and the levels of SCr and Cys-C in patients under 60 years old,and delay the progression of nephropathy.