Abstract：Objective：To observe the effect of Shenha Heche capsules combined with budesonide formoterol inhalation on cardiopulmonary function， coagulation function and inflammatory state in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods：A total of 108 patients with AECOPD were selected and divided into the control group and the treatment group according to different treatment methods，with 54 cases in each group. Both groups were given routine symptomatic treatment. The control group was additionally treated with budesonide formoterol inhalation， and the treatment group was additionally treated with Shenha Heche capsules based on the treatment of the control group. Before and after treatment， the clinical effects， cardiopulmonary function indexes[left ventricular ejection fraction(LVEF)， forced expiratory volume in one second(FEV1) and FEV1/forced vital capacity(FVC)]，coagulation function indexes [prothrombin time(PT)， activated partial thromboplastin time(APTT)， thrombin time(TT) and fibrinogen(Fib)]， and serum inflammatory factors [levels of interleukin- 8(IL- 8)， tumor necrosis factor- α(TNF- α)， and C- reactive protein(CRP)] were compared between the two groups. Results： The total effective rate was 94.44% in the treatment group and 77.78% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in levels of LVEF，FEV1 and FEV1/FVC between the two groups(P＞0.05). After treatment，the levels of LVEF，FEV1 and FEV1/FVC in the two groups were increased when compared with those before treatment(P＜0.05)， and the above indexes in the treatment group were higher than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of PT，APTT，Fib and TT between the two groups(P＞0.05). After treatment，the levels of PT，APTT and Fib in the two groups were improved when compared with those before treatment(P＜0.05)，and the improvement of the above three levels in the treatment group was more significant than that in the control group(P＜0.05)； before and after treatment，there was no significant difference being found in the comparison of TT levels between the two groups(P＞0.05). Before treatment， there was no significant difference being found in the comparison of levels of IL- 8， TNF- α and CRP between the two groups(P＞0.05)； after treatment， the above three levels in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three levels in the treatment group were lower than those in the control group(P＜0.05). Conclusion： The therapy of Shenha Heche capsules combined with budesonide formoterol inhalation has a remarkable curative effect on AECOPD， which can significantly alleviate the clinical symptoms of patients， effectively improve the cardiopulmonary function and coagulation function， and reduce the inflammatory responses of the body.