舒眠胶囊联合文拉法辛治疗抑郁症伴失眠临床研究
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R749.4

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Clinical Study on Shumian Capsules Combined with Venlafaxine for Depression Complicated with Insomnia
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    摘要:

    目的:观察舒眠胶囊联合文拉法辛治疗抑郁症伴失眠的临床疗效。方法:选取76 例抑郁症伴失眠患者,按随机数字表法分为对照组和观察组各38 例。对照组采用文拉法辛治疗,观察组给予舒眠胶囊联合文法拉辛治疗,2 组均治疗6 周。比较2 组治疗前后汉密尔顿抑郁量表(HAMD) -17、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)、Barthel 指数评分,比较2 组临床疗效。结果:治疗后,2 组HAMD-17、SDS、PSQI 评分均较治疗前降低(P<0.05),观察组HAMD-17、SDS、PSQI 评分均低于对照组(P<0.05)。治疗后,2 组Barthel 指数评分均较治疗前升高(P<0.05),观察组Barthel 指数评分高于对照组(P<0.05)。观察组总有效率94.74%,高于对照组73.68%(P<0.05)。结论:舒眠胶囊联合文拉法辛治疗抑郁症伴失眠疗效显著,可减轻患者的抑郁程度,改善其睡眠质量及日常生活能力。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Shumian capsules combined with venlafaxine for depression complicated with insomnia. Methods:A total of 76 depression patients complicated with insomnia were selected and divided into the control group and the observation group according to the random number table method,with 38 cases in each group. The control group was treated with venlafaxine, and the observation group was treated with Shumian capsules combined with venlafaxine. Both groups were treated for six weeks. Before and after treatment,the scores of Hamilton Rating Scale for Depression- 17(HAMD- 17), Self- Rating Depression Scale(SDS), Pittsburgh Sleep Quality Index(PSQI) and Barthel Index were compared between the two groups, and the clinical effects in the two groups were compared. Results: After treatment,the scores of HAMD-17,SDS and PSQI in the two groups were decreased when compared with those before treatment(P<0.05),and the above three scores in the observation group were lower than those in the control group(P<0.05). After treatment,the scores of Barthel Index in both groups were increased(P<0.05),and the score of Barthel Index in the observation group was higher(P<0.05). The total effective rate was 94.74% in the observation group, higher than that of 73.68% in the control group(P<0.05). Conclusion: The therapy of Shumian capsules combined with venlafaxine has a significant curative effect on depression complicated with insomnia,which can reduce the degree of depression in patients and improve their sleep quality and ability of daily living.

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修岩峰,潘秀娟.舒眠胶囊联合文拉法辛治疗抑郁症伴失眠临床研究[J].新中医,2022,54(10):92-94

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  • 在线发布日期: 2022-05-24
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