冠心宁片治疗肺源性心脏病急性加重期气滞血瘀证临床研究
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R541.5

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浙江省医学会临床科研基金项目(2019ZYC-A167)


Clinical Study on Guanxinning Tablets for Pulmonary Heart Disease in Acute Exacerba⁃ tion with Qi Stagnation and Blood Stasis Syndrome
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    摘要:

    目的:观察冠心宁片治疗肺源性心脏病急性加重期气滞血瘀证的临床疗效。方法:选取110 例肺源性心脏病急性加重期气滞血瘀证患者,按照随机数字表法分为对照组和观察组,每组55 例。对照组给予常规对症治疗,观察组在对照组基础上加用冠心宁片治疗,2 组均连续治疗4 周。比较2 组临床疗效及治疗前后心功能、肺功能。结果:观察组总有效率94.55%,高于对照组80.00%(P<0.05)。治疗后,2 组左室射血分数(LVEF)、每搏输出量(SV)、心输出量(CO)、第1 秒用力呼气容积占预计值的百分比(FEV1%pred)、第1 秒用力呼气容积(FEV1) /用力肺活量(FVC) 均较治疗前增大(P<0.05),观察组LVEF、SV、CO、FEV1%pred 及FEV1/FVC 均大于对照组(P<0.05)。结论:冠心宁片治疗肺源性心脏病急性加重期气滞血瘀证疗效较好,可有效改善患者的心肺功能。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Guanxinning tablets for pulmonary heart disease in acute exacerbation with qi stagnation and blood stasis syndrome. Methods:A total of 110 cases of patients with pulmonary heart disease in acute exacerbation with qi stagnation and blood stasis syndrome were selected and divided into the control group and the observation group according to the random number table method,with 55 cases in each group. The control group was given routine symptomatic treatment,and the observation group was additionally given Guanxinning tablets based on the treatment of the control group. Both groups were continuously treated for four weeks. The heart function and lung function before and after treatment as well as the clinical effects were compared between the two groups. Results: The total effective rate was 94.55% in the observation group, higher than that of 80.00% in the control group(P<0.05). After treatment, left ventricular ejection fraction(LVEF), stroke output(SV), cardiac output(CO), prcentage of forced expiratory volume in the first second to the expected value(FEV1%pred) and forced expiratory volume in the first second(FEV1) forced vital capacity(FVC) in the two groups were increased when compared with those before treatment(P<0.05), and the above indexes in the observation group were higher than those in the control group(P<0.05). Conclusion:Guanxinning tablets has a relatively good curative effect on pulmonary heart disease in acute exacerbation with qi stagnation and blood stasis syndrome and can effectively improve the heart function and lung function.

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何云飞,朱铁峰,郑小蓉,周成英,倪芷轩.冠心宁片治疗肺源性心脏病急性加重期气滞血瘀证临床研究[J].新中医,2022,54(10):81-83

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  • 在线发布日期: 2022-05-24
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