Abstract： Objective： To study the mechanism of Maxing Ersan tang in the treatment of bronchial asthma based on Network Pharmacology Database. Methods： The effective components and corresponding targets of Herba Ephedrae， Semen Armeniacae Amarum， Pericarpium Citri Reticulatae， Rhizoma Pinelliae， Poria， Fructus Perillae， Semen Raphani， Semen Sinapis， Fructus Chebulae and Radix et Rhizoma Glycyrrhizae were obtained from the Chinese Medicine System Pharmacology Database and Analysis Platform as well as PubChem Database. Bronchial asthma- related targets were obtained from Human Gene Database and Online Mendelian Inheritance In Man， and intersection genes were obtained by Venny 2.1 Online Network. Cytoscape(Version3.7.2) and STRING Database were used to construct network of drug- active component-target-disease and protein-protein interaction network，and then the plug-in of CytoHubba was used to identify core targets. Lastly，Metascape Database was used to analyze Gene Ontology(GO) enrichment analysis and kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis. Results：The main therapeutic targets of Maxing Ersan tang in treating bronchial asthma included vascular endothelial growth factor A(VEGFA)，interleukin- 6(IL- 6)，tumor necrosis factor (TNF)， avian sarcoma virus 17(JUN)， p53 tumor protein(TP53)， signal transducer and activator of transcription 3(STAT3)， mitogen- activated protein kinase 3(MAPK3) ， prostaglandin- endoperoxide synthase 2(PTGS2) ， mitogen- activated protein kinase 1(MAPK1) and Cysteine-aspartate protease-3(CASP3). The involved signaling pathways were phosphoinositol- 3- kinase- serine/threonine kinase(PI3K- AKT) signaling pathway， interleukin- 17(IL- 17) signaling pathway， advanced glycation end product- receptor of AGE(AGE- RAGE) signaling pathway， tumor necrosis factor(TNF) signaling pathway， tumor signaling pathway， etc. Conclusion： Maxing Ersan tang plays a role in treating bronchial asthma through multiple components，multiple targets and multiple pathways.