Abstract：Objective：To observe the clinical effect of point massage for hemodialysis complicated with muscle spasm. Methods： A total of 88 cases of patients with hemodialysis complicated with muscle spasm were selected and randomly divided into the control group and the observation group，with 44 cases in each group. The control group was given routine treatment，and the observation group was additionally given point massage based on routine treatment. The pain degree of muscle spasm， duration of muscle spasm， Modified Barthel Index(MBI) scores before and after treatment as well as the clinical effects and the incidences of complications in the two groups were compared. Results： After treatment， the total effective rate was 88.64% in the observation group， higher than that of 70.45% in the control group(P＜0.05). After treatment，pain indexes and duration of muscle spasm in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above indexes in the observation group were lower than those in the control group (P＜0.05). After treatment，MBI scores in the two groups were significantly higher than those before treatment，and MBI score in the observation group was higher than that in the control group(P＜0.05). During treatment， the incidence of complications in the observation group was significantly lower than that in the control group(P＜0.05). Conclusion： Point massage for hemodialysis complicated with muscle spasm can significantly improve the clinical effect，reduce pain，spasm duration and the incidence of complications，and improve the activity of daily living.