Abstract：Objective：To systematically evaluate the clinical efficacy the clinical efficacy of acupuncture and moxibustion combined with rehabilitation in the treatment of post- stroke depression. Methods： By computer and manual retrieval， literatures about clinical trials on acupuncture and moxibustion and rehabilitation in treating post-strokedepression published before October of 2020 were collected from China National Knowledge Infrastructure(CNKI)， WanFang database， Vip database，China Biology Medicine disc(CBMdisc)，PubMed，Web of Science，EMbase and The Cochrane Library. RevMan 5.3 software was used to input and analyze data， and the quality of included studies was evaluated one by one. Metaanalysis was performed on Hamilton Depression Scale(HAMD)， Activity of Daily Living Scale(ADL)， National Institute of Health Stroke Scale(NIHSS) and effective rate. Results： A total of 310 articles were retrieved and 11 articles were finally recruited， including 1 065 patients with post- stroke depression， 545 cases treated by acupuncture and moxibustion combined with rehabilitation， 371 by medicine and 149 by other single method.The Meta- analysis showed that needling combined with rehabilitation produced more significant effective rate than and [medicine(effective rate)： RR=1.20， 95% CI (1.12，1.29)，Z=4.96，P＜0.000 01]. Other single method(effective rate) [RR=1.26，95%CI(1.02，1.56)，Z=2.18，P＝0.03]. Moreover， needling combined with rehabilitation produced a better effect in improving nerve function， [NIHSS： WMD= 4.17， 95% CI(2.35， 6.00)， Z=4.49， P＜0.000 01].It can significantly improve the anxiety and depression of patients， [HAMD： WMD=4.20， 95% CI(3.35， 5.06)， Z=9.65， P＜0.000 01]， showing an advantage in activity of daily life[ADL： WMD=23.17， 95% CI(21.25， 25.09)， Z=23.65， P＜0.000 01]. Conclusion： Acupuncture and moxibustion combined with rehabilitation is effective in the treatment of post-stroke depression，which has certain reference value in clinical application and promotion. However，due to the quality of included researches need to be improved，its effectiveness should be treated with caution in application. In the future， high quality， large sample and multi- center randomized clinical studies are still needed to confirm.