风热清口服液联合头孢西丁治疗急性呼吸道感染临床研究
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R373.1

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Clinical Study on Fengreqing Oral Liquid Combined with Cefoxitin for Acute Respiratory Infection
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    摘要:

    目的:观察风热清口服液联合头孢西丁治疗急性呼吸道感染的临床疗效。方法:选取急性呼吸道感染患儿270 例,按照随机数字表法分为对照组和观察组各135 例。对照组给予头孢西丁注射液治疗,观察组在对照组的基础上给予风热清口服液治疗,连续治疗2 周。观察2 组治疗前后肺功能指标[潮气量(VT)、呼吸频率(RR)、呼吸时间比(Ti/Te) 和第1 秒用力呼气容积/用力肺活量(FEV1/FVC)]、炎症因子[白细胞介素-10(IL-10)、白细胞介素-13(IL-13)、C-反应蛋白(CRP) 和降钙素原(PCT)]水平、免疫指标(CD3+、CD4+、CD8+和CD4+/CD8+) 变化,比较2 组治疗后肺啰音消失时间、咳嗽消失时间、喘息消失时间、热退时间和临床疗效。结果:治疗后,2 组VT、FEV1/FVC、CD3+、CD4+、CD4+/CD8+水平高于治疗前(P<0.05),且观察组上述指标高于对照组(P<0.05)。治疗后,2 组RR、Ti/Te、IL-10、IL-13、CRP、PCT、CD8+水平低于治疗前(P<0.05),且观察组上述7 项指标均低于对照组(P<0.05)。治疗后,观察组肺啰音消失时间、咳嗽消失时间、喘息消失时间、热退时间低于对照组(P<0.05)。观察组总有效率为97.04%,高于对照组89.63%,差异有统计学意义(P<0.05)。结论:风热清口服液联合头孢西丁治疗可有效提高急性呼吸道感染临床疗效,改善机体免疫状态,减轻炎症损伤,促进肺功能恢复。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Fengreqing oral liquid combined with cefoxitin for acute respiratory infection. Methods:A total of 270 cases of children with acute respiratory infection were selected and divided into the control group and the observation group according to the random number table method,with 135 cases in each group. The control group was treated with cefoxitin injection, and the observation group was additionally treated with Fengreqing oral liquid based on the treatment of the control group. Both groups were continuously treated for two weeks. Changes in pulmonary function indexes[tidal volume(VT),respiratory rate(RR),respiratory time ratio(Ti / Te),the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)],levels of inflammatory factors [interleukin-10(IL-10),interleukin-13(IL-13), C-reactive protein(CRP) and procalcitonin(PCT)],and immune indexes(CD3+,CD4+,CD8+ and CD4+/CD8+) in the two groups were observed before and after treatment. The disappearance time of pulmonary rales, cough and wheezing, heat regression time and clinical effects were compared between the two groups. Results:After treatment,levels of VT,FEV1/ FVC,CD3 +,CD4 +,and CD4 +/CD8 + in the two groups were higher than those before treatment(P>0.05),and the above indexes in the observation group were higher than those in the control group(P<0.05). After treatment,levels of RR,Ti/Te, IL- 10,IL- 13,CRP,PCT and CD8 + in the two groups were lower than those before treatment(P>0.05),and the above seven indexes in the observation group were lower than those in the control group(P<0.05). After treatment, the disappearance time of pulmonary rales, cough and wheezing, and heat regression time in the observation group were shorter than those in the control group(P<0.05). The total effective rate was 97.04% in the observation group,higher than that of 89.63% in the control group,the difference being significant(P<0.05). Conclusion:Fengreqing oral liquid combined with cefoxitin can effectively enhance clinical effects in the treatment of acute respiratory infection,improve body immune state,alleviate inflammatory injury,and promote the recovery of the lung function.

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李芸蕊,张磊,刘阳,赵丽丽.风热清口服液联合头孢西丁治疗急性呼吸道感染临床研究[J].新中医,2022,54(9):72-76

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  • 在线发布日期: 2022-05-09
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